Association between HDL-C and chronic pain: data from the NHANES database 2003–2004
ObjectiveHigh-density lipoprotein cholesterol (HDL-C) has been reported to be associated with pain symptoms of various diseases, and its anti-inflammatory and antioxidant mediation is related to the pathogenesis of chronic pain. This study aims to evaluate the relationship between HDL-C levels and c...
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| Format: | Article |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1340037/full |
| _version_ | 1797266409674244096 |
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| author | Panpan Mi Haoran Dong Shengle Chen Xuan Gao Xu Cao Yong Liu Huijie Wang Guofeng Fan |
| author_facet | Panpan Mi Haoran Dong Shengle Chen Xuan Gao Xu Cao Yong Liu Huijie Wang Guofeng Fan |
| author_sort | Panpan Mi |
| collection | DOAJ |
| description | ObjectiveHigh-density lipoprotein cholesterol (HDL-C) has been reported to be associated with pain symptoms of various diseases, and its anti-inflammatory and antioxidant mediation is related to the pathogenesis of chronic pain. This study aims to evaluate the relationship between HDL-C levels and chronic pain in American adults.MethodsThis cross-sectional study used data from American adults aged 20 and above during the 2003–2004 National Health and Nutrition Examination Survey (NHANES) cycle. Participants were divided into 4 groups based on HDL-C quartiles. We used chi-square tests and Student’s t-tests or Mann-Whitney U tests to analyze categorical variables and continuous variables to compare differences between groups. Multivariate logistic regression analysis was used to study the association between HDL-C levels and the risk of chronic pain. Likelihood ratio tests were used to assess interactions between subgroups, and sensitivity analyses were conducted.ResultsOur final analysis included 4,688 participants, of which 733 (16.4%) had chronic pain. In the multivariate logistic regression model adjusted for covariates, there was a negative correlation between HDL-C levels and chronic pain. Specifically, for every 20 unit increase in HDL-C, the risk of chronic pain decreased by 26%. Compared with the lowest HDL-C quartile (< 43 mg/dL), the highest HDL-C quartile (≥ 64 mg/dL) was associated with a 24% reduction in the risk of chronic pain. No interaction factors affecting the relationship between HDL-C and chronic pain were found in the subgroup analysis.ConclusionThis study demonstrates a negative association between HDL-C levels and chronic pain in US adults, providing insights into the pathogenesis of chronic pain and potential improvements in chronic pain management strategies. |
| first_indexed | 2024-04-25T01:00:14Z |
| format | Article |
| id | doaj.art-2aac549c50604f9e825817b6d291b23c |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-25T01:00:14Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2aac549c50604f9e825817b6d291b23c2024-03-11T05:04:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-03-011110.3389/fmed.2024.13400371340037Association between HDL-C and chronic pain: data from the NHANES database 2003–2004Panpan Mi0Haoran Dong1Shengle Chen2Xuan Gao3Xu Cao4Yong Liu5Huijie Wang6Guofeng Fan7Department of Orthopedic, Hebei PetroChina Central Hospital, Langfang, ChinaHospital of Stomatology Hebei Medical University, Shijiazhuang, ChinaDepartment of Orthopedic, Hebei PetroChina Central Hospital, Langfang, ChinaDepartment of Orthopedic, Hebei PetroChina Central Hospital, Langfang, ChinaDepartment of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, ChinaDepartment of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, ChinaDepartment of Endoscopy, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, ChinaDepartment of Orthopedic, Hebei PetroChina Central Hospital, Langfang, ChinaObjectiveHigh-density lipoprotein cholesterol (HDL-C) has been reported to be associated with pain symptoms of various diseases, and its anti-inflammatory and antioxidant mediation is related to the pathogenesis of chronic pain. This study aims to evaluate the relationship between HDL-C levels and chronic pain in American adults.MethodsThis cross-sectional study used data from American adults aged 20 and above during the 2003–2004 National Health and Nutrition Examination Survey (NHANES) cycle. Participants were divided into 4 groups based on HDL-C quartiles. We used chi-square tests and Student’s t-tests or Mann-Whitney U tests to analyze categorical variables and continuous variables to compare differences between groups. Multivariate logistic regression analysis was used to study the association between HDL-C levels and the risk of chronic pain. Likelihood ratio tests were used to assess interactions between subgroups, and sensitivity analyses were conducted.ResultsOur final analysis included 4,688 participants, of which 733 (16.4%) had chronic pain. In the multivariate logistic regression model adjusted for covariates, there was a negative correlation between HDL-C levels and chronic pain. Specifically, for every 20 unit increase in HDL-C, the risk of chronic pain decreased by 26%. Compared with the lowest HDL-C quartile (< 43 mg/dL), the highest HDL-C quartile (≥ 64 mg/dL) was associated with a 24% reduction in the risk of chronic pain. No interaction factors affecting the relationship between HDL-C and chronic pain were found in the subgroup analysis.ConclusionThis study demonstrates a negative association between HDL-C levels and chronic pain in US adults, providing insights into the pathogenesis of chronic pain and potential improvements in chronic pain management strategies.https://www.frontiersin.org/articles/10.3389/fmed.2024.1340037/fullchronic painHDL-Cnegative correlationNHANEScross-sectional study |
| spellingShingle | Panpan Mi Haoran Dong Shengle Chen Xuan Gao Xu Cao Yong Liu Huijie Wang Guofeng Fan Association between HDL-C and chronic pain: data from the NHANES database 2003–2004 Frontiers in Medicine chronic pain HDL-C negative correlation NHANES cross-sectional study |
| title | Association between HDL-C and chronic pain: data from the NHANES database 2003–2004 |
| title_full | Association between HDL-C and chronic pain: data from the NHANES database 2003–2004 |
| title_fullStr | Association between HDL-C and chronic pain: data from the NHANES database 2003–2004 |
| title_full_unstemmed | Association between HDL-C and chronic pain: data from the NHANES database 2003–2004 |
| title_short | Association between HDL-C and chronic pain: data from the NHANES database 2003–2004 |
| title_sort | association between hdl c and chronic pain data from the nhanes database 2003 2004 |
| topic | chronic pain HDL-C negative correlation NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1340037/full |
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