Relationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort study
Abstract Background The prevalence of obesity, hypertension and diabetes is increasing. Hypertension and diabetes are common complications. Additionally, obesity and hypertension–diabetes comorbidity (HDC) are both closely related to insulin resistance. The aim of this study was to determine the ass...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-023-04510-z |
| _version_ | 1797414018933063680 |
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| author | Haojie Li Zhan Shi Xuejiao Chen Junjie Wang Jiacheng Ding Shuoji Geng Xinyuan Sheng Songhe Shi |
| author_facet | Haojie Li Zhan Shi Xuejiao Chen Junjie Wang Jiacheng Ding Shuoji Geng Xinyuan Sheng Songhe Shi |
| author_sort | Haojie Li |
| collection | DOAJ |
| description | Abstract Background The prevalence of obesity, hypertension and diabetes is increasing. Hypertension and diabetes are common complications. Additionally, obesity and hypertension–diabetes comorbidity (HDC) are both closely related to insulin resistance. The aim of this study was to determine the association of obesity indicators with HDC in elderly individuals. Methods This retrospective cohort study included 74,955 subjects aged ≥ 60 years living in Xinzheng, Henan Province, from January 2011 to December 2019. The data were collected from the annual health examination dataset. Cox proportional hazard regression models and competing-risk survival regression models were used to examine the relationships between the three indicators and HDC risk. Results After 346,504 person-years of follow-up, HDC developed in 9,647 subjects. After further adjustments for confounders and death competing risks, compared with a body mass index (BMI) of 18.5–23.9 kg/m2, the fully adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of BMI < 18.5, 24–27.9 and ≥ 28 kg/m2 for HDC morbidity were 0.651(0.538,0.788),1.00,1.396(1.336,1.459) and 1.769(1.666,1.878), respectively. Moreover, participants with abdominal obesity measured via waist circumference (WC) or waist-to-height ratio (WtHR) had a higher risk of HDC (HR:1.513; 95% CI: 1.45,1.578 and HR:1.412;95% CI: 1.353,1.473), respectively, than participants with low WC or with low WtHR. In the joint analyses, the highest risk was observed in participants who were overweight and who had central obesity (HR: 1.721; 95% CI: 1.635, 1.811) compared with the nonoverweight and noncentral obesity groups. Conclusions Increased BMI, WC and WtHR were associated with an increased risk of HDC. There was an additive interaction between general body adiposity (as measured via BMI) and central obesity (as measured via WC and WtHR) for HDC. Therefore, reasonable control of BMI, WC and WtHR may be an effective measure to prevent HDC among elderly individuals. |
| first_indexed | 2024-03-09T05:27:01Z |
| format | Article |
| id | doaj.art-2aae6b92165541baa32d4c98bfdbab4c |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-09T05:27:01Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-2aae6b92165541baa32d4c98bfdbab4c2023-12-03T12:35:38ZengBMCBMC Geriatrics1471-23182023-11-0123111010.1186/s12877-023-04510-zRelationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort studyHaojie Li0Zhan Shi1Xuejiao Chen2Junjie Wang3Jiacheng Ding4Shuoji Geng5Xinyuan Sheng6Songhe Shi7College of Public Health, Zhengzhou UniversityDepartment of Pharmacy, Zhengzhou People’s HospitalCollege of Public Health, Zhengzhou UniversityCollege of Public Health, Zhengzhou UniversityCollege of Public Health, Zhengzhou UniversityCollege of Public Health, Zhengzhou UniversityCollege of Public Health, Zhengzhou UniversityCollege of Public Health, Zhengzhou UniversityAbstract Background The prevalence of obesity, hypertension and diabetes is increasing. Hypertension and diabetes are common complications. Additionally, obesity and hypertension–diabetes comorbidity (HDC) are both closely related to insulin resistance. The aim of this study was to determine the association of obesity indicators with HDC in elderly individuals. Methods This retrospective cohort study included 74,955 subjects aged ≥ 60 years living in Xinzheng, Henan Province, from January 2011 to December 2019. The data were collected from the annual health examination dataset. Cox proportional hazard regression models and competing-risk survival regression models were used to examine the relationships between the three indicators and HDC risk. Results After 346,504 person-years of follow-up, HDC developed in 9,647 subjects. After further adjustments for confounders and death competing risks, compared with a body mass index (BMI) of 18.5–23.9 kg/m2, the fully adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of BMI < 18.5, 24–27.9 and ≥ 28 kg/m2 for HDC morbidity were 0.651(0.538,0.788),1.00,1.396(1.336,1.459) and 1.769(1.666,1.878), respectively. Moreover, participants with abdominal obesity measured via waist circumference (WC) or waist-to-height ratio (WtHR) had a higher risk of HDC (HR:1.513; 95% CI: 1.45,1.578 and HR:1.412;95% CI: 1.353,1.473), respectively, than participants with low WC or with low WtHR. In the joint analyses, the highest risk was observed in participants who were overweight and who had central obesity (HR: 1.721; 95% CI: 1.635, 1.811) compared with the nonoverweight and noncentral obesity groups. Conclusions Increased BMI, WC and WtHR were associated with an increased risk of HDC. There was an additive interaction between general body adiposity (as measured via BMI) and central obesity (as measured via WC and WtHR) for HDC. Therefore, reasonable control of BMI, WC and WtHR may be an effective measure to prevent HDC among elderly individuals.https://doi.org/10.1186/s12877-023-04510-zHypertension-diabetes comorbidityBody mass indexWaist circumferenceWaist-to-height ratioCohortElderly |
| spellingShingle | Haojie Li Zhan Shi Xuejiao Chen Junjie Wang Jiacheng Ding Shuoji Geng Xinyuan Sheng Songhe Shi Relationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort study BMC Geriatrics Hypertension-diabetes comorbidity Body mass index Waist circumference Waist-to-height ratio Cohort Elderly |
| title | Relationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort study |
| title_full | Relationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort study |
| title_fullStr | Relationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort study |
| title_full_unstemmed | Relationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort study |
| title_short | Relationship between obesity indicators and hypertension–diabetes comorbidity in an elderly population: a retrospective cohort study |
| title_sort | relationship between obesity indicators and hypertension diabetes comorbidity in an elderly population a retrospective cohort study |
| topic | Hypertension-diabetes comorbidity Body mass index Waist circumference Waist-to-height ratio Cohort Elderly |
| url | https://doi.org/10.1186/s12877-023-04510-z |
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