Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography study
The temporal pole (TP) is considered one of the major paralimbic cortical regions, and is involved in a variety of functions such as sensory perception, emotion, semantic processing, and social cognition. Based on differences in cytoarchitecture, the TP can be further subdivided into smaller regions...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2023.1240545/full |
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| author | Takeshi Sasaki Takeshi Sasaki Takeshi Sasaki Nikos Makris Nikos Makris Martha E. Shenton Martha E. Shenton Peter Savadjiev Peter Savadjiev Yogesh Rathi Ryan Eckbo Sylvain Bouix Sylvain Bouix Edward Yeterian Bradford C. Dickerson Marek Kubicki Marek Kubicki |
| author_facet | Takeshi Sasaki Takeshi Sasaki Takeshi Sasaki Nikos Makris Nikos Makris Martha E. Shenton Martha E. Shenton Peter Savadjiev Peter Savadjiev Yogesh Rathi Ryan Eckbo Sylvain Bouix Sylvain Bouix Edward Yeterian Bradford C. Dickerson Marek Kubicki Marek Kubicki |
| author_sort | Takeshi Sasaki |
| collection | DOAJ |
| description | The temporal pole (TP) is considered one of the major paralimbic cortical regions, and is involved in a variety of functions such as sensory perception, emotion, semantic processing, and social cognition. Based on differences in cytoarchitecture, the TP can be further subdivided into smaller regions (dorsal, ventrolateral and ventromedial), each forming key nodes of distinct functional networks. However, the brain structural connectivity profile of TP subregions is not fully clarified. Using diffusion MRI data in a set of 31 healthy subjects, we aimed to elucidate the comprehensive structural connectivity of three cytoarchitectonically distinct TP subregions. Diffusion tensor imaging (DTI) analysis suggested that major association fiber pathways such as the inferior longitudinal, middle longitudinal, arcuate, and uncinate fasciculi provide structural connectivity to the TP. Further analysis suggested partially overlapping yet still distinct structural connectivity patterns across the TP subregions. Specifically, the dorsal subregion is strongly connected with wide areas in the parietal lobe, the ventrolateral subregion with areas including constituents of the default-semantic network, and the ventromedial subregion with limbic and paralimbic areas. Our results suggest the involvement of the TP in a set of extensive but distinct networks of cortical regions, consistent with its functional roles. |
| first_indexed | 2024-03-09T14:23:25Z |
| format | Article |
| id | doaj.art-2aaebf60b1c943d0898801aa44b6c8f2 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-03-09T14:23:25Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-2aaebf60b1c943d0898801aa44b6c8f22023-11-28T08:54:02ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292023-11-011710.3389/fnana.2023.12405451240545Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography studyTakeshi Sasaki0Takeshi Sasaki1Takeshi Sasaki2Nikos Makris3Nikos Makris4Martha E. Shenton5Martha E. Shenton6Peter Savadjiev7Peter Savadjiev8Yogesh Rathi9Ryan Eckbo10Sylvain Bouix11Sylvain Bouix12Edward Yeterian13Bradford C. Dickerson14Marek Kubicki15Marek Kubicki16Psychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesCenter for Morphometric Analysis, Department of Psychiatry, Neurology, and Radiology Services, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United StatesDepartment of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, JapanPsychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesCenter for Morphometric Analysis, Department of Psychiatry, Neurology, and Radiology Services, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United StatesPsychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesPsychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesPsychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesFrontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United StatesPsychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Software Engineering and Information Technology, École de Technologie Supérieure, Montréal, QC, CanadaDepartment of Psychology, Colby College, Waterville, ME, United StatesFrontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United StatesPsychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesCenter for Morphometric Analysis, Department of Psychiatry, Neurology, and Radiology Services, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United StatesThe temporal pole (TP) is considered one of the major paralimbic cortical regions, and is involved in a variety of functions such as sensory perception, emotion, semantic processing, and social cognition. Based on differences in cytoarchitecture, the TP can be further subdivided into smaller regions (dorsal, ventrolateral and ventromedial), each forming key nodes of distinct functional networks. However, the brain structural connectivity profile of TP subregions is not fully clarified. Using diffusion MRI data in a set of 31 healthy subjects, we aimed to elucidate the comprehensive structural connectivity of three cytoarchitectonically distinct TP subregions. Diffusion tensor imaging (DTI) analysis suggested that major association fiber pathways such as the inferior longitudinal, middle longitudinal, arcuate, and uncinate fasciculi provide structural connectivity to the TP. Further analysis suggested partially overlapping yet still distinct structural connectivity patterns across the TP subregions. Specifically, the dorsal subregion is strongly connected with wide areas in the parietal lobe, the ventrolateral subregion with areas including constituents of the default-semantic network, and the ventromedial subregion with limbic and paralimbic areas. Our results suggest the involvement of the TP in a set of extensive but distinct networks of cortical regions, consistent with its functional roles.https://www.frontiersin.org/articles/10.3389/fnana.2023.1240545/fulltemporal polestructural connectivitydiffusion tensor imagingtractographycytoarchitecturedefault mode network |
| spellingShingle | Takeshi Sasaki Takeshi Sasaki Takeshi Sasaki Nikos Makris Nikos Makris Martha E. Shenton Martha E. Shenton Peter Savadjiev Peter Savadjiev Yogesh Rathi Ryan Eckbo Sylvain Bouix Sylvain Bouix Edward Yeterian Bradford C. Dickerson Marek Kubicki Marek Kubicki Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography study Frontiers in Neuroanatomy temporal pole structural connectivity diffusion tensor imaging tractography cytoarchitecture default mode network |
| title | Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography study |
| title_full | Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography study |
| title_fullStr | Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography study |
| title_full_unstemmed | Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography study |
| title_short | Structural connectivity of cytoarchitectonically distinct human left temporal pole subregions: a diffusion MRI tractography study |
| title_sort | structural connectivity of cytoarchitectonically distinct human left temporal pole subregions a diffusion mri tractography study |
| topic | temporal pole structural connectivity diffusion tensor imaging tractography cytoarchitecture default mode network |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2023.1240545/full |
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