Progress of Different Programmed Cell Death Pathways in Kidney Cancer
Programmed cell death (PCD) is a genetically determined, active and orderly cell death in the organism, and it affects the evolution of the organism, maintenance of its homeostasis, and development of several tissues and organs. The abnormal regulation of this process is closely related to various h...
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Format: | Article |
Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2023-05-01
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Series: | Zhongliu Fangzhi Yanjiu |
Subjects: | |
Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1100 |
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author | WU Mingzhe WANG Fuchun PAN Haojie ZHOU An'an XIAO Xi TIAN Junqiang |
author_facet | WU Mingzhe WANG Fuchun PAN Haojie ZHOU An'an XIAO Xi TIAN Junqiang |
author_sort | WU Mingzhe |
collection | DOAJ |
description | Programmed cell death (PCD) is a genetically determined, active and orderly cell death in the organism, and it affects the evolution of the organism, maintenance of its homeostasis, and development of several tissues and organs. The abnormal regulation of this process is closely related to various human diseases, including cancer. The identified pathways of PCD include apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, which can be activated when cells are stimulated by various internal and external environmental factors. These pathways can induce cell death or maintain cell survival in kidney cancer cells under the regulation of various signaling molecules, thus affecting tumor progression or therapeutic efficacy. In this paper, the role of these PCD pathways in the development of kidney cancer was reviewed in light of recent research advances to provide new directions for the in-depth study of the pathogenesis of kidney cancer and the development of targeted antitumor drugs. |
first_indexed | 2024-03-13T06:44:02Z |
format | Article |
id | doaj.art-2aaf674435494d10860854e98920f57b |
institution | Directory Open Access Journal |
issn | 1000-8578 |
language | zho |
last_indexed | 2024-03-13T06:44:02Z |
publishDate | 2023-05-01 |
publisher | Magazine House of Cancer Research on Prevention and Treatment |
record_format | Article |
series | Zhongliu Fangzhi Yanjiu |
spelling | doaj.art-2aaf674435494d10860854e98920f57b2023-06-08T10:42:08ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-05-0150553153710.3971/j.issn.1000-8578.2023.22.11008578.2023.22.1100Progress of Different Programmed Cell Death Pathways in Kidney CancerWU Mingzhe0WANG Fuchun1PAN Haojie2ZHOU An'an3XIAO Xi4TIAN Junqiang5Department of Urology, The Second Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Urology, The Second Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Urology, The Second Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Urology, The Second Hospital of Lanzhou University, Lanzhou 730000, ChinaDepartment of Urology, The Second Hospital of Lanzhou University, Lanzhou 730000, ChinaProgrammed cell death (PCD) is a genetically determined, active and orderly cell death in the organism, and it affects the evolution of the organism, maintenance of its homeostasis, and development of several tissues and organs. The abnormal regulation of this process is closely related to various human diseases, including cancer. The identified pathways of PCD include apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, which can be activated when cells are stimulated by various internal and external environmental factors. These pathways can induce cell death or maintain cell survival in kidney cancer cells under the regulation of various signaling molecules, thus affecting tumor progression or therapeutic efficacy. In this paper, the role of these PCD pathways in the development of kidney cancer was reviewed in light of recent research advances to provide new directions for the in-depth study of the pathogenesis of kidney cancer and the development of targeted antitumor drugs.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1100kidney cancerprogrammed cell deathapoptosisautophagynecroptosispyroptosisferroptosis |
spellingShingle | WU Mingzhe WANG Fuchun PAN Haojie ZHOU An'an XIAO Xi TIAN Junqiang Progress of Different Programmed Cell Death Pathways in Kidney Cancer Zhongliu Fangzhi Yanjiu kidney cancer programmed cell death apoptosis autophagy necroptosis pyroptosis ferroptosis |
title | Progress of Different Programmed Cell Death Pathways in Kidney Cancer |
title_full | Progress of Different Programmed Cell Death Pathways in Kidney Cancer |
title_fullStr | Progress of Different Programmed Cell Death Pathways in Kidney Cancer |
title_full_unstemmed | Progress of Different Programmed Cell Death Pathways in Kidney Cancer |
title_short | Progress of Different Programmed Cell Death Pathways in Kidney Cancer |
title_sort | progress of different programmed cell death pathways in kidney cancer |
topic | kidney cancer programmed cell death apoptosis autophagy necroptosis pyroptosis ferroptosis |
url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1100 |
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