| Summary: | Three new and uncommon chromone analogs, epiremisporine F (<b>1</b>), epiremisporine G (<b>2</b>), and epiremisporine H (<b>3</b>), were isolated from marine-origin <i>Penicillium citrinum</i>. Among the isolated compounds, compounds <b>2</b>–<b>3</b> remarkably suppressed fMLP-induced superoxide anion generation by human neutrophils, with IC<sub>50</sub> values of 31.68 ± 2.53, and 33.52 ± 0.42 μM, respectively. Compound <b>3</b> exhibited cytotoxic activities against human colon carcinoma (HT-29) and non-small lung cancer cell (A549) with IC<sub>50</sub> values of 21.17 ± 4.89 and 31.43 ± 3.01 μM, respectively, and Western blot assay confirmed that compound <b>3</b> obviously induced apoptosis of HT-29 cells, via Bcl-2, Bax, and caspase 3 signaling cascades.
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