Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis
Objective To evaluate the effects of silver and iodine dressings on healing time, healing rate, exudate amount, pain and anti-infective efficacy.Design Systematic review and meta-analysis.Data sources Databases including PubMed, Cochrane Library, Embase, Web of Science and CINAHL were surveyed up to...
| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artikel |
| Taal: | English |
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BMJ Publishing Group
2024-08-01
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| Reeks: | BMJ Open |
| Online toegang: | https://bmjopen.bmj.com/content/14/8/e077902.full |
| _version_ | 1827147464486944768 |
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| author | Maritta Välimäki Yan Jiang Jia Guo Hongjuan Wang Qiuhong Zhou Qijian Zhang Weiwei Dai |
| author_facet | Maritta Välimäki Yan Jiang Jia Guo Hongjuan Wang Qiuhong Zhou Qijian Zhang Weiwei Dai |
| author_sort | Maritta Välimäki |
| collection | DOAJ |
| description | Objective To evaluate the effects of silver and iodine dressings on healing time, healing rate, exudate amount, pain and anti-infective efficacy.Design Systematic review and meta-analysis.Data sources Databases including PubMed, Cochrane Library, Embase, Web of Science and CINAHL were surveyed up to May 2024.Eligibility criteria Randomised controlled trials comparing silver and iodine dressings on wound healing in humans.Data extraction and synthesis Evidence certainty was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation approach. Data extraction was done independently by two reviewers, with the risk of bias assessed using the Cochrane tool. Narrative synthesis was performed to evaluate the effects of silver and iodine dressings on healing time, healing rate, pain, exudate amount and anti-infective efficacy. Meta-analysis using Review Manager V.5.4 calculated standardised mean differences for healing time and relative risks for rate to quantify the impacts of the treatments.Results 17 studies (18 articles) were included. The meta-analysis indicated that silver dressings significantly reduced healing time compared with iodine dressings (SMD=-0.95, 95% CI −1.62 to −0.28, I2=92%, p=0.005, moderate-quality evidence), with no significant difference in enhancing healing rate (RR=1.29, 95% CI 0.90 to 1.85, I2=91%, p=0.16, low-quality evidence). Based on low-quality evidence, for exudate amount (3/17), 66.7% (2/3) of the studies favoured silver dressings over iodine in reducing exudate volume. For pain (7/17), 57.1% (4/7) of the studies reported no significant difference between silver and iodine dressings, while 42.9% (3/7) studies indicated superior pain relief with silver dressings. For anti-infective efficacy (11/13), 54.5% (6/11) of the studies showed equivalence between silver and iodine dressings, while 36.4% (4/11) suggested greater antibacterial efficacy for silver.Conclusion Silver dressings, demonstrating a comparable healing rate to iodine dressings, significantly reduce healing time, suggesting their potential as a superior adjunct in wound care.PROSPERO registration number CRD42020199602. |
| first_indexed | 2025-03-20T20:46:49Z |
| format | Article |
| id | doaj.art-2aafa3ca205840e3b4c3ca21c0b4be13 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-03-20T20:46:49Z |
| publishDate | 2024-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-2aafa3ca205840e3b4c3ca21c0b4be132024-08-15T02:15:10ZengBMJ Publishing GroupBMJ Open2044-60552024-08-0114810.1136/bmjopen-2023-077902Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysisMaritta Välimäki0Yan Jiang1Jia Guo2Hongjuan Wang3Qiuhong Zhou4Qijian Zhang5Weiwei Dai61 Xiangya School of Nursing, Central South University, Changsha, Hunan, China1 Xiangya School of Nursing, Central South University, Changsha, Hunan, China1 Xiangya School of Nursing, Central South University, Changsha, Hunan, China1 Xiangya School of Nursing, Central South University, Changsha, Hunan, China3 Teaching and Research Section of Clinical Nursing, Xiangya Hospital Central South University, Changsha, Hunan, China3 Teaching and Research Section of Clinical Nursing, Xiangya Hospital Central South University, Changsha, Hunan, China2 Xiangya Center for Evidence-Based Nursing Practice & Healthcare Innovation: A JBI Center of Excellence, Changsha, ChinaObjective To evaluate the effects of silver and iodine dressings on healing time, healing rate, exudate amount, pain and anti-infective efficacy.Design Systematic review and meta-analysis.Data sources Databases including PubMed, Cochrane Library, Embase, Web of Science and CINAHL were surveyed up to May 2024.Eligibility criteria Randomised controlled trials comparing silver and iodine dressings on wound healing in humans.Data extraction and synthesis Evidence certainty was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation approach. Data extraction was done independently by two reviewers, with the risk of bias assessed using the Cochrane tool. Narrative synthesis was performed to evaluate the effects of silver and iodine dressings on healing time, healing rate, pain, exudate amount and anti-infective efficacy. Meta-analysis using Review Manager V.5.4 calculated standardised mean differences for healing time and relative risks for rate to quantify the impacts of the treatments.Results 17 studies (18 articles) were included. The meta-analysis indicated that silver dressings significantly reduced healing time compared with iodine dressings (SMD=-0.95, 95% CI −1.62 to −0.28, I2=92%, p=0.005, moderate-quality evidence), with no significant difference in enhancing healing rate (RR=1.29, 95% CI 0.90 to 1.85, I2=91%, p=0.16, low-quality evidence). Based on low-quality evidence, for exudate amount (3/17), 66.7% (2/3) of the studies favoured silver dressings over iodine in reducing exudate volume. For pain (7/17), 57.1% (4/7) of the studies reported no significant difference between silver and iodine dressings, while 42.9% (3/7) studies indicated superior pain relief with silver dressings. For anti-infective efficacy (11/13), 54.5% (6/11) of the studies showed equivalence between silver and iodine dressings, while 36.4% (4/11) suggested greater antibacterial efficacy for silver.Conclusion Silver dressings, demonstrating a comparable healing rate to iodine dressings, significantly reduce healing time, suggesting their potential as a superior adjunct in wound care.PROSPERO registration number CRD42020199602.https://bmjopen.bmj.com/content/14/8/e077902.full |
| spellingShingle | Maritta Välimäki Yan Jiang Jia Guo Hongjuan Wang Qiuhong Zhou Qijian Zhang Weiwei Dai Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis BMJ Open |
| title | Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis |
| title_full | Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis |
| title_fullStr | Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis |
| title_full_unstemmed | Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis |
| title_short | Effectiveness of silver and iodine dressings on wound healing: a systematic review and meta-analysis |
| title_sort | effectiveness of silver and iodine dressings on wound healing a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/14/8/e077902.full |
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