Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes
Influenza continues to represent a major threat to public health, and the development of monoclonal antibodies (mAbs) that provide broad protection remains a key avenue for therapeutic development. Here, the authors demonstrate the molecular basis of neutralization for a human bnAb (PN-SIA28) agains...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35236-y |
| _version_ | 1828092542132944896 |
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| author | Yulu Chen Fei Wang Liwei Yin Haihai Jiang Xishan Lu Yuhai Bi Wei Zhang Yi Shi Roberto Burioni Zhou Tong Hao Song Jianxun Qi George F. Gao |
| author_facet | Yulu Chen Fei Wang Liwei Yin Haihai Jiang Xishan Lu Yuhai Bi Wei Zhang Yi Shi Roberto Burioni Zhou Tong Hao Song Jianxun Qi George F. Gao |
| author_sort | Yulu Chen |
| collection | DOAJ |
| description | Influenza continues to represent a major threat to public health, and the development of monoclonal antibodies (mAbs) that provide broad protection remains a key avenue for therapeutic development. Here, the authors demonstrate the molecular basis of neutralization for a human bnAb (PN-SIA28) against both endemic influenza A and emerging pathogens such as bat H17 and H18 viruses. |
| first_indexed | 2024-04-11T06:29:14Z |
| format | Article |
| id | doaj.art-2ab16417772846538d05804fee7be288 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T06:29:14Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2ab16417772846538d05804fee7be2882022-12-22T04:40:11ZengNature PortfolioNature Communications2041-17232022-12-0113111310.1038/s41467-022-35236-yStructural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypesYulu Chen0Fei Wang1Liwei Yin2Haihai Jiang3Xishan Lu4Yuhai Bi5Wei Zhang6Yi Shi7Roberto Burioni8Zhou Tong9Hao Song10Jianxun Qi11George F. Gao12CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesUniversità Vita-Salute San RaffaeleCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesUniversity of Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesInfluenza continues to represent a major threat to public health, and the development of monoclonal antibodies (mAbs) that provide broad protection remains a key avenue for therapeutic development. Here, the authors demonstrate the molecular basis of neutralization for a human bnAb (PN-SIA28) against both endemic influenza A and emerging pathogens such as bat H17 and H18 viruses.https://doi.org/10.1038/s41467-022-35236-y |
| spellingShingle | Yulu Chen Fei Wang Liwei Yin Haihai Jiang Xishan Lu Yuhai Bi Wei Zhang Yi Shi Roberto Burioni Zhou Tong Hao Song Jianxun Qi George F. Gao Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes Nature Communications |
| title | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes |
| title_full | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes |
| title_fullStr | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes |
| title_full_unstemmed | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes |
| title_short | Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes |
| title_sort | structural basis for a human broadly neutralizing influenza a hemagglutinin stem specific antibody including h17 18 subtypes |
| url | https://doi.org/10.1038/s41467-022-35236-y |
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