Improved Efficiency of Pomegranate Seed Oil Administrated Nasally
Pomegranate seed oil (PSO) is currently administrated orally as a food supplement for improving memory. However, the efficiency of the oral dosage forms for such purposes is low, mainly due to the blood brain barrier impeding a good delivery to brain. In this work, we designed and characterized a PS...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/5/918 |
| _version_ | 1827667338821894144 |
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| author | Hiba Natsheh Elka Touitou |
| author_facet | Hiba Natsheh Elka Touitou |
| author_sort | Hiba Natsheh |
| collection | DOAJ |
| description | Pomegranate seed oil (PSO) is currently administrated orally as a food supplement for improving memory. However, the efficiency of the oral dosage forms for such purposes is low, mainly due to the blood brain barrier impeding a good delivery to brain. In this work, we designed and characterized a PSO phospholipid oily gel for nasal administration. We tested the performance of the new PSO delivery system in animal models for impaired memory and locomotor activity. The experimental results indicated a statistically significant improvement (<i>p</i> < 0.05) of more than 1.5 fold in the behavior of animals treated nasally, in comparison to those treated with orally administrated oil. Furthermore, in multiphoton microscopy and near infrared imaging studies, the nasal administration of fluorescent probes, fluorescein isothiocyanate (FITC), and indocyanine green (ICG) incorporated in the PSO system showed enhanced delivery to the brain. Results of the histopathologic examination of the nasal cavity and mucosa, as carried out by a pathologist, indicated the safety of the PSO phospholipid oily gel. In conclusion, the results of this work encourage further investigation of the phospholipid oily gel composition as a new way of PSO administration. |
| first_indexed | 2024-03-10T03:08:19Z |
| format | Article |
| id | doaj.art-2ab1b3dc7d014548944b5b3f2509356a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:08:19Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-2ab1b3dc7d014548944b5b3f2509356a2023-11-23T12:36:28ZengMDPI AGPharmaceutics1999-49232022-04-0114591810.3390/pharmaceutics14050918Improved Efficiency of Pomegranate Seed Oil Administrated NasallyHiba Natsheh0Elka Touitou1The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, IsraelThe Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, IsraelPomegranate seed oil (PSO) is currently administrated orally as a food supplement for improving memory. However, the efficiency of the oral dosage forms for such purposes is low, mainly due to the blood brain barrier impeding a good delivery to brain. In this work, we designed and characterized a PSO phospholipid oily gel for nasal administration. We tested the performance of the new PSO delivery system in animal models for impaired memory and locomotor activity. The experimental results indicated a statistically significant improvement (<i>p</i> < 0.05) of more than 1.5 fold in the behavior of animals treated nasally, in comparison to those treated with orally administrated oil. Furthermore, in multiphoton microscopy and near infrared imaging studies, the nasal administration of fluorescent probes, fluorescein isothiocyanate (FITC), and indocyanine green (ICG) incorporated in the PSO system showed enhanced delivery to the brain. Results of the histopathologic examination of the nasal cavity and mucosa, as carried out by a pathologist, indicated the safety of the PSO phospholipid oily gel. In conclusion, the results of this work encourage further investigation of the phospholipid oily gel composition as a new way of PSO administration.https://www.mdpi.com/1999-4923/14/5/918pomegranate seed oilnasal delivery systemmemory impairmentmovement impairmentdelivery to brainimproved memory |
| spellingShingle | Hiba Natsheh Elka Touitou Improved Efficiency of Pomegranate Seed Oil Administrated Nasally Pharmaceutics pomegranate seed oil nasal delivery system memory impairment movement impairment delivery to brain improved memory |
| title | Improved Efficiency of Pomegranate Seed Oil Administrated Nasally |
| title_full | Improved Efficiency of Pomegranate Seed Oil Administrated Nasally |
| title_fullStr | Improved Efficiency of Pomegranate Seed Oil Administrated Nasally |
| title_full_unstemmed | Improved Efficiency of Pomegranate Seed Oil Administrated Nasally |
| title_short | Improved Efficiency of Pomegranate Seed Oil Administrated Nasally |
| title_sort | improved efficiency of pomegranate seed oil administrated nasally |
| topic | pomegranate seed oil nasal delivery system memory impairment movement impairment delivery to brain improved memory |
| url | https://www.mdpi.com/1999-4923/14/5/918 |
| work_keys_str_mv | AT hibanatsheh improvedefficiencyofpomegranateseedoiladministratednasally AT elkatouitou improvedefficiencyofpomegranateseedoiladministratednasally |