Wnt Inhibition Sensitizes PD-L1 Blockade Therapy by Overcoming Bone Marrow-Derived Myofibroblasts-Mediated Immune Resistance in Tumors

Wnt Inhibition Sensitizes PD-L1 Blockade Therapy by Overcoming Bone Marrow-Derived Myofibroblasts-Mediated Immune Resistance in Tumors

Cancer-associated fibroblasts (CAFs) has been recognized as one cause of tumor resistance to immune checkpoint blockade therapy, but the underlying mechanisms still remain elusive. In the present study, a bone marrow-derived CAF (BMF) -rich tumor model is successfully established by subcutaneously m...

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Bibliographic Details
Main Authors: Tinglei Huang, Fuli Li, Xiaojiao Cheng, Jianzheng Wang, Wenhui Zhang, Baiwen Zhang, Yao Tang, Qingli Li, Cong Zhou, Shuiping Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
immunotherapy resistance
programmed cell death ligand 1
immune checkpoint blockers
cancer-associated fibroblasts
bone marrow-derived myofibroblasts
Wnt/β-catenin signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.619209/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.619209/full

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