Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
Caspase-1, activated by stress in immune cells and in CNS human neurons, may contribute to neuronal degeneration. Here, the authors investigate the therapeutic potential of a Caspase-1 inhibitor in a mouse model of Alzheimer’s disease.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06449-x |
| _version_ | 1818978089073377280 |
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| author | Joseph Flores Anastasia Noël Bénédicte Foveau Jeffrey Lynham Clotilde Lecrux Andréa C. LeBlanc |
| author_facet | Joseph Flores Anastasia Noël Bénédicte Foveau Jeffrey Lynham Clotilde Lecrux Andréa C. LeBlanc |
| author_sort | Joseph Flores |
| collection | DOAJ |
| description | Caspase-1, activated by stress in immune cells and in CNS human neurons, may contribute to neuronal degeneration. Here, the authors investigate the therapeutic potential of a Caspase-1 inhibitor in a mouse model of Alzheimer’s disease. |
| first_indexed | 2024-12-20T16:38:05Z |
| format | Article |
| id | doaj.art-2ab3ce42e3eb4a95a13cf8e46e06bf48 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:38:05Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2ab3ce42e3eb4a95a13cf8e46e06bf482022-12-21T19:33:06ZengNature PortfolioNature Communications2041-17232018-09-019111410.1038/s41467-018-06449-xCaspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse modelJoseph Flores0Anastasia Noël1Bénédicte Foveau2Jeffrey Lynham3Clotilde Lecrux4Andréa C. LeBlanc5Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalDepartment of Neurology and Neurosurgery, McGill UniversityBloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General HospitalCaspase-1, activated by stress in immune cells and in CNS human neurons, may contribute to neuronal degeneration. Here, the authors investigate the therapeutic potential of a Caspase-1 inhibitor in a mouse model of Alzheimer’s disease.https://doi.org/10.1038/s41467-018-06449-x |
| spellingShingle | Joseph Flores Anastasia Noël Bénédicte Foveau Jeffrey Lynham Clotilde Lecrux Andréa C. LeBlanc Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model Nature Communications |
| title | Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model |
| title_full | Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model |
| title_fullStr | Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model |
| title_full_unstemmed | Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model |
| title_short | Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model |
| title_sort | caspase 1 inhibition alleviates cognitive impairment and neuropathology in an alzheimer s disease mouse model |
| url | https://doi.org/10.1038/s41467-018-06449-x |
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