Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
Elderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06920-9 |
| _version_ | 1818419839412207616 |
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| author | Julius Gudmundsson Jon K. Sigurdsson Lilja Stefansdottir Bjarni A. Agnarsson Helgi J. Isaksson Olafur A. Stefansson Sigurjon A. Gudjonsson Daniel F. Gudbjartsson Gisli Masson Michael L. Frigge Simon N. Stacey Patrick Sulem Gisli H. Halldorsson Vinicius Tragante Hilma Holm Gudmundur I. Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Thorvaldur Jonsson Eirikur Jonsson Rosa B. Barkardottir Rafn Hilmarsson Folkert W. Asselbergs Gudmundur Geirsson Unnur Thorsteinsdottir Thorunn Rafnar Gudmar Thorleifsson Kari Stefansson |
| author_facet | Julius Gudmundsson Jon K. Sigurdsson Lilja Stefansdottir Bjarni A. Agnarsson Helgi J. Isaksson Olafur A. Stefansson Sigurjon A. Gudjonsson Daniel F. Gudbjartsson Gisli Masson Michael L. Frigge Simon N. Stacey Patrick Sulem Gisli H. Halldorsson Vinicius Tragante Hilma Holm Gudmundur I. Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Thorvaldur Jonsson Eirikur Jonsson Rosa B. Barkardottir Rafn Hilmarsson Folkert W. Asselbergs Gudmundur Geirsson Unnur Thorsteinsdottir Thorunn Rafnar Gudmar Thorleifsson Kari Stefansson |
| author_sort | Julius Gudmundsson |
| collection | DOAJ |
| description | Elderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14 loci, and 15 of these variants associate with prostate specific antigen, which is linked to prostate cancer risk. |
| first_indexed | 2024-12-14T12:44:57Z |
| format | Article |
| id | doaj.art-2ab3f1af06ec4c619f53cc3075130ef0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:44:57Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2ab3f1af06ec4c619f53cc3075130ef02022-12-21T23:00:48ZengNature PortfolioNature Communications2041-17232018-11-01911810.1038/s41467-018-06920-9Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSAJulius Gudmundsson0Jon K. Sigurdsson1Lilja Stefansdottir2Bjarni A. Agnarsson3Helgi J. Isaksson4Olafur A. Stefansson5Sigurjon A. Gudjonsson6Daniel F. Gudbjartsson7Gisli Masson8Michael L. Frigge9Simon N. Stacey10Patrick Sulem11Gisli H. Halldorsson12Vinicius Tragante13Hilma Holm14Gudmundur I. Eyjolfsson15Olof Sigurdardottir16Isleifur Olafsson17Thorvaldur Jonsson18Eirikur Jonsson19Rosa B. Barkardottir20Rafn Hilmarsson21Folkert W. Asselbergs22Gudmundur Geirsson23Unnur Thorsteinsdottir24Thorunn Rafnar25Gudmar Thorleifsson26Kari Stefansson27deCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENLandspitali-University HospitalLandspitali-University HospitaldeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENThe Clinical Laboratory in MjoddDepartment of Clinical Biochemistry, Akureyri HospitalLandspitali-University HospitalLandspitali-University HospitalLandspitali-University HospitalLaboratory of Cell Biology, Department of Pathology, Landspitali University HospitalLandspitali-University HospitalDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of UtrechtLandspitali-University HospitaldeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENdeCODE genetics/AMGENElderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14 loci, and 15 of these variants associate with prostate specific antigen, which is linked to prostate cancer risk.https://doi.org/10.1038/s41467-018-06920-9 |
| spellingShingle | Julius Gudmundsson Jon K. Sigurdsson Lilja Stefansdottir Bjarni A. Agnarsson Helgi J. Isaksson Olafur A. Stefansson Sigurjon A. Gudjonsson Daniel F. Gudbjartsson Gisli Masson Michael L. Frigge Simon N. Stacey Patrick Sulem Gisli H. Halldorsson Vinicius Tragante Hilma Holm Gudmundur I. Eyjolfsson Olof Sigurdardottir Isleifur Olafsson Thorvaldur Jonsson Eirikur Jonsson Rosa B. Barkardottir Rafn Hilmarsson Folkert W. Asselbergs Gudmundur Geirsson Unnur Thorsteinsdottir Thorunn Rafnar Gudmar Thorleifsson Kari Stefansson Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA Nature Communications |
| title | Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_full | Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_fullStr | Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_full_unstemmed | Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_short | Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| title_sort | genome wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of psa |
| url | https://doi.org/10.1038/s41467-018-06920-9 |
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