COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population
This review compared coronavirus disease 2019 (COVID-19) laboratory findings, comorbidities, and clinical outcomes in patients from the general population versus medical staff to aid diagnosis of COVID-19 in a more timely, efficient, and accurate way. Electronic databases were searched up to 23rd Ma...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korea Disease Control and Prevention Agency
2020-10-01
|
| Series: | Osong Public Health and Research Perspectives |
| Subjects: | |
| Online Access: | http://ophrp.org/upload/pdf/ophrp-11-269.pdf |
| _version_ | 1797711361303642112 |
|---|---|
| author | Mina Ebrahimi Amal Saki Malehi Fakher Rahim |
| author_facet | Mina Ebrahimi Amal Saki Malehi Fakher Rahim |
| author_sort | Mina Ebrahimi |
| collection | DOAJ |
| description | This review compared coronavirus disease 2019 (COVID-19) laboratory findings, comorbidities, and clinical outcomes in patients from the general population versus medical staff to aid diagnosis of COVID-19 in a more timely, efficient, and accurate way. Electronic databases were searched up to 23rd March, 2020. The initial search yielded 6,527 studies. Following screening, 24 studies were included [18 studies (11,564 cases) of confirmed COVID-19 cases in the general public, and 6 studies (394 cases) in medical staff] in this review. Significant differences were observed in white blood cell counts (p < 0.001), lymphocyte counts (p < 0.001), platelet counts (p = 0.04), procalcitonin levels (p < 0.001), lactate dehydrogenase levels (p < 0.001), and creatinine levels (p = 0.03) when comparing infected medical staff with the general public. The mortality rate was higher in the general population than in medical staff (8% versus 2%). This review showed that during the early stages of COVID-19, laboratory findings alone may not be significant predictors of infection and may just accompany increasing C-reactive protein levels, erythrocyte sedimentation rates, and lactate dehydrogenase levels. In the symptomatic stage, the lymphocyte and platelet counts tended to decrease. Elevated D-dimer fibrin degradation product was associated with poor prognosis. |
| first_indexed | 2024-03-12T07:04:51Z |
| format | Article |
| id | doaj.art-2ab5ecc28d294804845d51dc2fb78906 |
| institution | Directory Open Access Journal |
| issn | 2210-9099 2210-9110 |
| language | English |
| last_indexed | 2024-03-12T07:04:51Z |
| publishDate | 2020-10-01 |
| publisher | Korea Disease Control and Prevention Agency |
| record_format | Article |
| series | Osong Public Health and Research Perspectives |
| spelling | doaj.art-2ab5ecc28d294804845d51dc2fb789062023-09-02T23:27:28ZengKorea Disease Control and Prevention AgencyOsong Public Health and Research Perspectives2210-90992210-91102020-10-0111526927910.24171/j.phrp.2020.11.5.02581COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General PopulationMina Ebrahimi0Amal Saki Malehi1Fakher Rahim2 Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranThis review compared coronavirus disease 2019 (COVID-19) laboratory findings, comorbidities, and clinical outcomes in patients from the general population versus medical staff to aid diagnosis of COVID-19 in a more timely, efficient, and accurate way. Electronic databases were searched up to 23rd March, 2020. The initial search yielded 6,527 studies. Following screening, 24 studies were included [18 studies (11,564 cases) of confirmed COVID-19 cases in the general public, and 6 studies (394 cases) in medical staff] in this review. Significant differences were observed in white blood cell counts (p < 0.001), lymphocyte counts (p < 0.001), platelet counts (p = 0.04), procalcitonin levels (p < 0.001), lactate dehydrogenase levels (p < 0.001), and creatinine levels (p = 0.03) when comparing infected medical staff with the general public. The mortality rate was higher in the general population than in medical staff (8% versus 2%). This review showed that during the early stages of COVID-19, laboratory findings alone may not be significant predictors of infection and may just accompany increasing C-reactive protein levels, erythrocyte sedimentation rates, and lactate dehydrogenase levels. In the symptomatic stage, the lymphocyte and platelet counts tended to decrease. Elevated D-dimer fibrin degradation product was associated with poor prognosis.http://ophrp.org/upload/pdf/ophrp-11-269.pdfcovid-19meta-analysisprognostic factorssystematic review |
| spellingShingle | Mina Ebrahimi Amal Saki Malehi Fakher Rahim COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population Osong Public Health and Research Perspectives covid-19 meta-analysis prognostic factors systematic review |
| title | COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population |
| title_full | COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population |
| title_fullStr | COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population |
| title_full_unstemmed | COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population |
| title_short | COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population |
| title_sort | covid 19 patients a systematic review and meta analysis of laboratory findings comorbidities and clinical outcomes comparing medical staff versus the general population |
| topic | covid-19 meta-analysis prognostic factors systematic review |
| url | http://ophrp.org/upload/pdf/ophrp-11-269.pdf |
| work_keys_str_mv | AT minaebrahimi covid19patientsasystematicreviewandmetaanalysisoflaboratoryfindingscomorbiditiesandclinicaloutcomescomparingmedicalstaffversusthegeneralpopulation AT amalsakimalehi covid19patientsasystematicreviewandmetaanalysisoflaboratoryfindingscomorbiditiesandclinicaloutcomescomparingmedicalstaffversusthegeneralpopulation AT fakherrahim covid19patientsasystematicreviewandmetaanalysisoflaboratoryfindingscomorbiditiesandclinicaloutcomescomparingmedicalstaffversusthegeneralpopulation |