Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis
Successful treatment for any type of carcinoma largely depends on understanding the patterns of invasion and migration. For oral squamous cell carcinoma (OSCC), these processes are not entirely understood as of now. Invadopodia and podosomes, called invadosomes, play an important role in cancer cell...
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MDPI AG
2023-08-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/8/437 |
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| author | Immanuel Desel Susanne Jung Nikolai Purcz Yahya Açil Christoph Sproll Johannes Kleinheinz Sonja Sielker |
| author_facet | Immanuel Desel Susanne Jung Nikolai Purcz Yahya Açil Christoph Sproll Johannes Kleinheinz Sonja Sielker |
| author_sort | Immanuel Desel |
| collection | DOAJ |
| description | Successful treatment for any type of carcinoma largely depends on understanding the patterns of invasion and migration. For oral squamous cell carcinoma (OSCC), these processes are not entirely understood as of now. Invadopodia and podosomes, called invadosomes, play an important role in cancer cell invasion and migration. Previous research has established that cortactin (<i>CTTN</i>) is a major inducer of invadosome formation. However, less is known about the expression patterns of <i>CTTN</i> and other genes related to it or invadopodia formation in OSCC during tumor progression in particular. In this study, gene expression patterns of CTTN and various genes (n = 36) associated with invadopodia formation were analyzed to reveal relevant expression patterns and give a comprehensive overview of them. The genes were analyzed from a whole genome dataset of 83 OSCC samples relating to tumor size, grading, lymph node status, and UICC (Union for Internatioanl Cancer Control). The data revealed significant overexpression of 18 genes, most notably <i>CTTN</i>, <i>SRC</i> (SRC proto-onocogene, non-receptor tyrosine kinase)<i>, EGFR</i> (epidermal growth factor receptor), <i>SYK</i> (spleen associated tyrosine kinase), <i>WASL</i> (WASP like actin nucleation promotion factor), and <i>ARPC2</i> (arrestin beta 1) due to their significant correlation with further tumor parameters. This study is one of the first to summarize the expression patterns of <i>CTTN</i> and related genes in a complex group of OSCC samples. |
| first_indexed | 2024-03-11T00:00:59Z |
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| language | English |
| last_indexed | 2024-03-11T00:00:59Z |
| publishDate | 2023-08-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj.art-2ab79c6833ba4150b769868289be5a9f2023-11-19T00:42:15ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-08-014586927694010.3390/cimb45080437Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression AnalysisImmanuel Desel0Susanne Jung1Nikolai Purcz2Yahya Açil3Christoph Sproll4Johannes Kleinheinz5Sonja Sielker6Vascular Biology of Oral Structures (VABOS) Research Unit, Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, 48149 Muenster, GermanyVascular Biology of Oral Structures (VABOS) Research Unit, Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Cranio-Maxillofacial Surgery, University Hospital Kiel, 24105 Kiel, GermanyDepartment of Cranio-Maxillofacial Surgery, University Hospital Kiel, 24105 Kiel, GermanyDepartment of Cranio-Maxillofacial Surgery, University Hospital Duesseldorf, 40225 Duesseldorf, GermanyVascular Biology of Oral Structures (VABOS) Research Unit, Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, 48149 Muenster, GermanyVascular Biology of Oral Structures (VABOS) Research Unit, Department of Cranio-Maxillofacial Surgery, University Hospital Muenster, 48149 Muenster, GermanySuccessful treatment for any type of carcinoma largely depends on understanding the patterns of invasion and migration. For oral squamous cell carcinoma (OSCC), these processes are not entirely understood as of now. Invadopodia and podosomes, called invadosomes, play an important role in cancer cell invasion and migration. Previous research has established that cortactin (<i>CTTN</i>) is a major inducer of invadosome formation. However, less is known about the expression patterns of <i>CTTN</i> and other genes related to it or invadopodia formation in OSCC during tumor progression in particular. In this study, gene expression patterns of CTTN and various genes (n = 36) associated with invadopodia formation were analyzed to reveal relevant expression patterns and give a comprehensive overview of them. The genes were analyzed from a whole genome dataset of 83 OSCC samples relating to tumor size, grading, lymph node status, and UICC (Union for Internatioanl Cancer Control). The data revealed significant overexpression of 18 genes, most notably <i>CTTN</i>, <i>SRC</i> (SRC proto-onocogene, non-receptor tyrosine kinase)<i>, EGFR</i> (epidermal growth factor receptor), <i>SYK</i> (spleen associated tyrosine kinase), <i>WASL</i> (WASP like actin nucleation promotion factor), and <i>ARPC2</i> (arrestin beta 1) due to their significant correlation with further tumor parameters. This study is one of the first to summarize the expression patterns of <i>CTTN</i> and related genes in a complex group of OSCC samples.https://www.mdpi.com/1467-3045/45/8/437OSCC<i>CTTN</i>invadopodiaoral squamous cell carcinomacortactingene expression |
| spellingShingle | Immanuel Desel Susanne Jung Nikolai Purcz Yahya Açil Christoph Sproll Johannes Kleinheinz Sonja Sielker Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis Current Issues in Molecular Biology OSCC <i>CTTN</i> invadopodia oral squamous cell carcinoma cortactin gene expression |
| title | Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis |
| title_full | Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis |
| title_fullStr | Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis |
| title_full_unstemmed | Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis |
| title_short | Analysis of Genes Related to Invadopodia Formation and CTTN in Oral Squamous Cell Carcinoma—A Systematic Gene Expression Analysis |
| title_sort | analysis of genes related to invadopodia formation and cttn in oral squamous cell carcinoma a systematic gene expression analysis |
| topic | OSCC <i>CTTN</i> invadopodia oral squamous cell carcinoma cortactin gene expression |
| url | https://www.mdpi.com/1467-3045/45/8/437 |
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