Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes

Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes

Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads to the dysregulation of glucose homeostasis, which culminates in the onset of type 2 diabetes (T2D). FFA, which accum...

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Bibliographic Details
Main Authors: Jeanne Guitton, Cécile L. Bandet, Mohamed L. Mariko, Sophie Tan-Chen, Olivier Bourron, Yacir Benomar, Eric Hajduch, Hervé Le Stunff
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
Sphingosine-1-phosphate
obesity
type 2 diabetes
insulin resistance
pancreatic β cell fate
hypothalamus
Online Access:https://www.mdpi.com/2073-4409/9/7/1682

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