Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center Analysis
Background: Red blood cells (RBC) scintigraphy can be used not only for detection of bleeding sites, but also of spleen tissue. However, there is no established quantitative readout. Therefore, we investigated uptake in suspected splenic lesions in direct quantitative correlation to sites of physiol...
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MDPI AG
2022-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/2/486 |
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| author | Adrien Holzgreve Friederike Völter Astrid Delker Wolfgang G. Kunz Matthias P. Fabritius Matthias Brendel Nathalie L. Albert Peter Bartenstein Marcus Unterrainer Lena M. Unterrainer |
| author_facet | Adrien Holzgreve Friederike Völter Astrid Delker Wolfgang G. Kunz Matthias P. Fabritius Matthias Brendel Nathalie L. Albert Peter Bartenstein Marcus Unterrainer Lena M. Unterrainer |
| author_sort | Adrien Holzgreve |
| collection | DOAJ |
| description | Background: Red blood cells (RBC) scintigraphy can be used not only for detection of bleeding sites, but also of spleen tissue. However, there is no established quantitative readout. Therefore, we investigated uptake in suspected splenic lesions in direct quantitative correlation to sites of physiologic uptake in order to objectify the readout. Methods: 20 patients with Tc-99m-labelled RBC scintigraphy and SPECT/low-dose CT for assessment of suspected splenic tissue were included. Lesions were rated as vital splenic or non-splenic tissue, and uptake and physiologic uptake of bone marrow, pancreas, and spleen were then quantified using a volume-of-interest based approach. Hepatic uptake served as a reference. Results: The median uptake ratio was significantly higher in splenic (2.82 (range, 0.58–24.10), <i>n</i> = 47) compared to other lesions (0.49 (0.01–0.83), <i>n</i> = 7), <i>p</i> < 0.001, and 5 lesions were newly discovered. The median pancreatic uptake was 0.09 (range 0.03–0.67), bone marrow 0.17 (0.03–0.45), and orthotopic spleen 14.45 (3.04–29.82). Compared to orthotopic spleens, the pancreas showed lowest uptake (0.09 vs. 14.45, <i>p</i> = 0.004). Based on pancreatic uptake we defined a cutoff (0.75) to distinguish splenic from other tissues. Conclusion: As the uptake in extra-splenic regions is invariably low compared to splenules, it can be used as comparator for evaluating suspected splenic tissues. |
| first_indexed | 2024-03-09T22:10:09Z |
| format | Article |
| id | doaj.art-2ab95b0afca641008e76c119a07b869b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T22:10:09Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2ab95b0afca641008e76c119a07b869b2023-11-23T19:32:55ZengMDPI AGDiagnostics2075-44182022-02-0112248610.3390/diagnostics12020486Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center AnalysisAdrien Holzgreve0Friederike Völter1Astrid Delker2Wolfgang G. Kunz3Matthias P. Fabritius4Matthias Brendel5Nathalie L. Albert6Peter Bartenstein7Marcus Unterrainer8Lena M. Unterrainer9Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Radiology, University Hospital, LMU Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, GermanyBackground: Red blood cells (RBC) scintigraphy can be used not only for detection of bleeding sites, but also of spleen tissue. However, there is no established quantitative readout. Therefore, we investigated uptake in suspected splenic lesions in direct quantitative correlation to sites of physiologic uptake in order to objectify the readout. Methods: 20 patients with Tc-99m-labelled RBC scintigraphy and SPECT/low-dose CT for assessment of suspected splenic tissue were included. Lesions were rated as vital splenic or non-splenic tissue, and uptake and physiologic uptake of bone marrow, pancreas, and spleen were then quantified using a volume-of-interest based approach. Hepatic uptake served as a reference. Results: The median uptake ratio was significantly higher in splenic (2.82 (range, 0.58–24.10), <i>n</i> = 47) compared to other lesions (0.49 (0.01–0.83), <i>n</i> = 7), <i>p</i> < 0.001, and 5 lesions were newly discovered. The median pancreatic uptake was 0.09 (range 0.03–0.67), bone marrow 0.17 (0.03–0.45), and orthotopic spleen 14.45 (3.04–29.82). Compared to orthotopic spleens, the pancreas showed lowest uptake (0.09 vs. 14.45, <i>p</i> = 0.004). Based on pancreatic uptake we defined a cutoff (0.75) to distinguish splenic from other tissues. Conclusion: As the uptake in extra-splenic regions is invariably low compared to splenules, it can be used as comparator for evaluating suspected splenic tissues.https://www.mdpi.com/2075-4418/12/2/486selective spleen scintigraphyRBCsplenosissplenuleaccessory spleenperitoneal carcinomatosis |
| spellingShingle | Adrien Holzgreve Friederike Völter Astrid Delker Wolfgang G. Kunz Matthias P. Fabritius Matthias Brendel Nathalie L. Albert Peter Bartenstein Marcus Unterrainer Lena M. Unterrainer Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center Analysis Diagnostics selective spleen scintigraphy RBC splenosis splenule accessory spleen peritoneal carcinomatosis |
| title | Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center Analysis |
| title_full | Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center Analysis |
| title_fullStr | Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center Analysis |
| title_full_unstemmed | Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center Analysis |
| title_short | Detection of Splenic Tissue Using <sup>99m</sup>Tc-Labelled Denatured Red Blood Cells Scintigraphy—A Quantitative Single Center Analysis |
| title_sort | detection of splenic tissue using sup 99m sup tc labelled denatured red blood cells scintigraphy a quantitative single center analysis |
| topic | selective spleen scintigraphy RBC splenosis splenule accessory spleen peritoneal carcinomatosis |
| url | https://www.mdpi.com/2075-4418/12/2/486 |
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