Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy
<p>Abstract</p> <p>Background</p> <p>Smoking in pregnancy remains a public health challenge. Nicotine replacement therapy (NRT) is effective for smoking cessation in non-pregnant people, but because women metabolise nicotine and cotinine much faster in pregnancy, it is...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-01-01
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| Series: | BMC Health Services Research |
| Online Access: | http://www.biomedcentral.com/1472-6963/7/2 |
| _version_ | 1818068153793511424 |
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| author | Coughtrie Michael WH Watts Kim Lewis Sarah Britton John Thornton Jim Coleman Tim Mannion Clare Marlow Neil Godfrey Christine |
| author_facet | Coughtrie Michael WH Watts Kim Lewis Sarah Britton John Thornton Jim Coleman Tim Mannion Clare Marlow Neil Godfrey Christine |
| author_sort | Coughtrie Michael WH |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Smoking in pregnancy remains a public health challenge. Nicotine replacement therapy (NRT) is effective for smoking cessation in non-pregnant people, but because women metabolise nicotine and cotinine much faster in pregnancy, it is unclear whether this will be effective for smoking cessation in pregnancy. The NHS Health Technology Assessment Programme (HTA)-funded smoking, nicotine and pregnancy (SNAP) trial will investigate whether or not nicotine replacement therapy (NRT) is effective, cost-effective and safe when used for smoking cessation by pregnant women.</p> <p>Methods/Design</p> <p>Over two years, in 5 trial centres, 1050 pregnant women who are between 12 and 24 weeks pregnant will be randomised as they attend hospital for ante-natal ultrasound scans. Women will receive either nicotine or placebo transdermal patches with behavioural support. The primary outcome measure is biochemically-validated, self-reported, prolonged and total abstinence from smoking between a quit date (defined before randomisation and set within two weeks of this) and delivery. At six months after childbirth self-reported maternal smoking status will be ascertained and two years after childbirth, self-reported maternal smoking status and the behaviour, cognitive development and respiratory symptoms of children born in the trial will be compared in both groups.</p> <p>Discussion</p> <p>This trial is designed to ascertain whether or not standard doses of NRT (as transdermal patches) are effective and safe when used for smoking cessation during pregnancy.</p> |
| first_indexed | 2024-12-10T15:35:03Z |
| format | Article |
| id | doaj.art-2ab9737d3dbe4d36bf057ec5a993e0ea |
| institution | Directory Open Access Journal |
| issn | 1472-6963 |
| language | English |
| last_indexed | 2024-12-10T15:35:03Z |
| publishDate | 2007-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Health Services Research |
| spelling | doaj.art-2ab9737d3dbe4d36bf057ec5a993e0ea2022-12-22T01:43:15ZengBMCBMC Health Services Research1472-69632007-01-0171210.1186/1472-6963-7-2Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancyCoughtrie Michael WHWatts KimLewis SarahBritton JohnThornton JimColeman TimMannion ClareMarlow NeilGodfrey Christine<p>Abstract</p> <p>Background</p> <p>Smoking in pregnancy remains a public health challenge. Nicotine replacement therapy (NRT) is effective for smoking cessation in non-pregnant people, but because women metabolise nicotine and cotinine much faster in pregnancy, it is unclear whether this will be effective for smoking cessation in pregnancy. The NHS Health Technology Assessment Programme (HTA)-funded smoking, nicotine and pregnancy (SNAP) trial will investigate whether or not nicotine replacement therapy (NRT) is effective, cost-effective and safe when used for smoking cessation by pregnant women.</p> <p>Methods/Design</p> <p>Over two years, in 5 trial centres, 1050 pregnant women who are between 12 and 24 weeks pregnant will be randomised as they attend hospital for ante-natal ultrasound scans. Women will receive either nicotine or placebo transdermal patches with behavioural support. The primary outcome measure is biochemically-validated, self-reported, prolonged and total abstinence from smoking between a quit date (defined before randomisation and set within two weeks of this) and delivery. At six months after childbirth self-reported maternal smoking status will be ascertained and two years after childbirth, self-reported maternal smoking status and the behaviour, cognitive development and respiratory symptoms of children born in the trial will be compared in both groups.</p> <p>Discussion</p> <p>This trial is designed to ascertain whether or not standard doses of NRT (as transdermal patches) are effective and safe when used for smoking cessation during pregnancy.</p>http://www.biomedcentral.com/1472-6963/7/2 |
| spellingShingle | Coughtrie Michael WH Watts Kim Lewis Sarah Britton John Thornton Jim Coleman Tim Mannion Clare Marlow Neil Godfrey Christine Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy BMC Health Services Research |
| title | Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy |
| title_full | Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy |
| title_fullStr | Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy |
| title_full_unstemmed | Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy |
| title_short | Protocol for the <it><ul>S</ul></it>moking, <it><ul>N</ul></it>icotine <it><ul>a</ul></it>nd <it><ul>P</ul></it>regnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy |
| title_sort | protocol for the it ul s ul it moking it ul n ul it icotine it ul a ul it nd it ul p ul it regnancy snap trial double blind placebo randomised controlled trial of nicotine replacement therapy in pregnancy |
| url | http://www.biomedcentral.com/1472-6963/7/2 |
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