EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTS
The objective: to evaluate the efficiency of chemotherapy with bedaquiline in pulmonary tuberculosis patients with multiple drug resistance Subjects and methods. The chemotherapy efficiency was studied in 70 tuberculosis patients with extensive (XDR) or multiple (MDR) drug resistance who were treate...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2018-03-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1091 |
| _version_ | 1797696664347082752 |
|---|---|
| author | A. M. Tikhonov M. V. Burаkovа E. V. Vаniev V. V. Romаnov I. A. Vаsilyevа |
| author_facet | A. M. Tikhonov M. V. Burаkovа E. V. Vаniev V. V. Romаnov I. A. Vаsilyevа |
| author_sort | A. M. Tikhonov |
| collection | DOAJ |
| description | The objective: to evaluate the efficiency of chemotherapy with bedaquiline in pulmonary tuberculosis patients with multiple drug resistance Subjects and methods. The chemotherapy efficiency was studied in 70 tuberculosis patients with extensive (XDR) or multiple (MDR) drug resistance who were treated in clinics of Central Tuberculosis Research Institute All patients were divided into 3 groups: Group 1 (10 persons) included MDR TB patients, Group 2 (32 persons) included pre-XDR TB patients, Group 3 (28 persons) included XDR TB patientsResults of the study. High treatment efficiency in this difficult category of pulmonary tuberculosis patients with MDR and XDR was achieved when bedaquiline was added to the chemotherapy regimen Upon the completion of the main treatment course with bedaquiline, in the group of patients with MDR and pre-XDR the sputum conversion was achieved in 100%, and in XDR tuberculosis patients the sputum conversion rate made 893% The long-term treatment course with bedaquiline promoted the fastest sputum conversion, healing of cavities in the lungs of patients with disseminated tuberculosis and XDR, and it was not associated with a higher frequency of adverse events |
| first_indexed | 2024-03-12T03:29:38Z |
| format | Article |
| id | doaj.art-2abaae790cd44ea186657064c3af0ca1 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T03:29:38Z |
| publishDate | 2018-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-2abaae790cd44ea186657064c3af0ca12023-09-03T13:29:15ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062018-03-01962222610.21292/2075-1230-2018-96-2-22-261091EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTSA. M. Tikhonov0M. V. Burаkovа1E. V. Vаniev2V. V. Romаnov3I. A. Vаsilyevа4ФГБНУ «Центральный научно-исследовательский институт туберкулеза», МоскваФГБНУ «Центральный научно-исследовательский институт туберкулеза», Москва; ФГАОУ ВО «Российский университет дружбы народов», МоскваФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний», МоскваФГБНУ «Центральный научно-исследовательский институт туберкулеза», МоскваФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний», МоскваThe objective: to evaluate the efficiency of chemotherapy with bedaquiline in pulmonary tuberculosis patients with multiple drug resistance Subjects and methods. The chemotherapy efficiency was studied in 70 tuberculosis patients with extensive (XDR) or multiple (MDR) drug resistance who were treated in clinics of Central Tuberculosis Research Institute All patients were divided into 3 groups: Group 1 (10 persons) included MDR TB patients, Group 2 (32 persons) included pre-XDR TB patients, Group 3 (28 persons) included XDR TB patientsResults of the study. High treatment efficiency in this difficult category of pulmonary tuberculosis patients with MDR and XDR was achieved when bedaquiline was added to the chemotherapy regimen Upon the completion of the main treatment course with bedaquiline, in the group of patients with MDR and pre-XDR the sputum conversion was achieved in 100%, and in XDR tuberculosis patients the sputum conversion rate made 893% The long-term treatment course with bedaquiline promoted the fastest sputum conversion, healing of cavities in the lungs of patients with disseminated tuberculosis and XDR, and it was not associated with a higher frequency of adverse eventshttps://www.tibl-journal.com/jour/article/view/1091туберкулез легкихлекарственная устойчивость микобактерий туберкулезаэффективность химиотерапии |
| spellingShingle | A. M. Tikhonov M. V. Burаkovа E. V. Vаniev V. V. Romаnov I. A. Vаsilyevа EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTS Туберкулез и болезни лёгких туберкулез легких лекарственная устойчивость микобактерий туберкулеза эффективность химиотерапии |
| title | EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTS |
| title_full | EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTS |
| title_fullStr | EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTS |
| title_full_unstemmed | EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTS |
| title_short | EFFICIENCY OF CHEMOTHERAPY WITH BEDAQUILINE IN DRUG RESISTANT PULMONARY TUBERCULOSIS PATIENTS |
| title_sort | efficiency of chemotherapy with bedaquiline in drug resistant pulmonary tuberculosis patients |
| topic | туберкулез легких лекарственная устойчивость микобактерий туберкулеза эффективность химиотерапии |
| url | https://www.tibl-journal.com/jour/article/view/1091 |
| work_keys_str_mv | AT amtikhonov efficiencyofchemotherapywithbedaquilineindrugresistantpulmonarytuberculosispatients AT mvburakova efficiencyofchemotherapywithbedaquilineindrugresistantpulmonarytuberculosispatients AT evvaniev efficiencyofchemotherapywithbedaquilineindrugresistantpulmonarytuberculosispatients AT vvromanov efficiencyofchemotherapywithbedaquilineindrugresistantpulmonarytuberculosispatients AT iavasilyeva efficiencyofchemotherapywithbedaquilineindrugresistantpulmonarytuberculosispatients |