Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control study
<p>Abstract</p> <p>Background</p> <p>Several studies have shown that variants in the glucokinase regulatory protein gene (<it>GCKR</it>) were associated with type 2 diabetes and dyslipidemia. The purpose of this study was to examine whether tag single nucleo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-05-01
|
| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/12/66 |
| _version_ | 1819280523065819136 |
|---|---|
| author | Lu Daru Gu Qian Chen Hongyan Li Xiaomu Ling Yan Gao Xin |
| author_facet | Lu Daru Gu Qian Chen Hongyan Li Xiaomu Ling Yan Gao Xin |
| author_sort | Lu Daru |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Several studies have shown that variants in the glucokinase regulatory protein gene (<it>GCKR</it>) were associated with type 2 diabetes and dyslipidemia. The purpose of this study was to examine whether tag single nucleotide polymorphisms (SNPs) in the <it>GCKR </it>region were associated with type 2 diabetes and related traits in a Han Chinese population and to identify the potential mechanisms underlying these associations.</p> <p>Methods</p> <p>We investigated the association of polymorphisms in the <it>GCKR </it>gene with type 2 diabetes by employing a case-control study design (1118 cases and 1161 controls). Four tag SNPs (rs8179206, rs2293572, rs3817588 and rs780094) with pairwise r<sup>2 </sup>> 0.8 and minor allele frequency > 0.05 across the <it>GCKR </it>gene and its flanking regions were studied and haplotypes were constructed. Genotyping was performed by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy using a MassARRAY platform.</p> <p>Results</p> <p>The G alleles of <it>GCKR </it>rs3817588 and rs780094 were associated with an increased risk of type 2 diabetes after adjustment for year of birth, sex and BMI (OR = 1.24, 95% CI 1.08-1.43, p = 0.002 and OR = 1.22, 95% CI 1.07-1.38, p = 0.002, respectively). In the non-diabetic controls, the GG carriers of rs3817588 and rs780094 were nominally associated with a lower plasma triglyceride level compared to the AA carriers after adjustment for year of birth, sex and BMI (p for trend = 0.00004 and 0.03, respectively). Furthermore, the association of rs3817588 with plasma triglyceride level was still significant after correcting for multiple testing.</p> <p>Conclusions</p> <p>The rs3817588 A/G polymorphism of the <it>GCKR </it>gene was associated with type 2 diabetes and plasma triglyceride level in the Han Chinese population.</p> |
| first_indexed | 2024-12-24T00:45:09Z |
| format | Article |
| id | doaj.art-2abbbd5c0a4c416f84251f262902ba22 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-24T00:45:09Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-2abbbd5c0a4c416f84251f262902ba222022-12-21T17:23:49ZengBMCBMC Medical Genetics1471-23502011-05-011216610.1186/1471-2350-12-66Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control studyLu DaruGu QianChen HongyanLi XiaomuLing YanGao Xin<p>Abstract</p> <p>Background</p> <p>Several studies have shown that variants in the glucokinase regulatory protein gene (<it>GCKR</it>) were associated with type 2 diabetes and dyslipidemia. The purpose of this study was to examine whether tag single nucleotide polymorphisms (SNPs) in the <it>GCKR </it>region were associated with type 2 diabetes and related traits in a Han Chinese population and to identify the potential mechanisms underlying these associations.</p> <p>Methods</p> <p>We investigated the association of polymorphisms in the <it>GCKR </it>gene with type 2 diabetes by employing a case-control study design (1118 cases and 1161 controls). Four tag SNPs (rs8179206, rs2293572, rs3817588 and rs780094) with pairwise r<sup>2 </sup>> 0.8 and minor allele frequency > 0.05 across the <it>GCKR </it>gene and its flanking regions were studied and haplotypes were constructed. Genotyping was performed by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy using a MassARRAY platform.</p> <p>Results</p> <p>The G alleles of <it>GCKR </it>rs3817588 and rs780094 were associated with an increased risk of type 2 diabetes after adjustment for year of birth, sex and BMI (OR = 1.24, 95% CI 1.08-1.43, p = 0.002 and OR = 1.22, 95% CI 1.07-1.38, p = 0.002, respectively). In the non-diabetic controls, the GG carriers of rs3817588 and rs780094 were nominally associated with a lower plasma triglyceride level compared to the AA carriers after adjustment for year of birth, sex and BMI (p for trend = 0.00004 and 0.03, respectively). Furthermore, the association of rs3817588 with plasma triglyceride level was still significant after correcting for multiple testing.</p> <p>Conclusions</p> <p>The rs3817588 A/G polymorphism of the <it>GCKR </it>gene was associated with type 2 diabetes and plasma triglyceride level in the Han Chinese population.</p>http://www.biomedcentral.com/1471-2350/12/66 |
| spellingShingle | Lu Daru Gu Qian Chen Hongyan Li Xiaomu Ling Yan Gao Xin Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control study BMC Medical Genetics |
| title | Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
| title_full | Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
| title_fullStr | Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
| title_full_unstemmed | Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
| title_short | Associations of common polymorphisms in <it>GCKR </it>with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
| title_sort | associations of common polymorphisms in it gckr it with type 2 diabetes and related traits in a han chinese population a case control study |
| url | http://www.biomedcentral.com/1471-2350/12/66 |
| work_keys_str_mv | AT ludaru associationsofcommonpolymorphismsinitgckritwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT guqian associationsofcommonpolymorphismsinitgckritwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT chenhongyan associationsofcommonpolymorphismsinitgckritwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT lixiaomu associationsofcommonpolymorphismsinitgckritwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT lingyan associationsofcommonpolymorphismsinitgckritwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT gaoxin associationsofcommonpolymorphismsinitgckritwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy |