Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization
Summary: Vascular restenosis is the main factor affecting the prognosis of angioplasty in cardiovascular diseases, and inflammation is a central link in the progression of restenosis. Previous research that applies interleukin 10 (IL10) nanoparticles can effectively regulate local inflammation, but...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222014195 |
| _version_ | 1811339359119474688 |
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| author | Fengshi Li Zhihua Rong Rui Zhang Shuai Niu Xiao Di Leng Ni Changwei Liu |
| author_facet | Fengshi Li Zhihua Rong Rui Zhang Shuai Niu Xiao Di Leng Ni Changwei Liu |
| author_sort | Fengshi Li |
| collection | DOAJ |
| description | Summary: Vascular restenosis is the main factor affecting the prognosis of angioplasty in cardiovascular diseases, and inflammation is a central link in the progression of restenosis. Previous research that applies interleukin 10 (IL10) nanoparticles can effectively regulate local inflammation, but their targeted delivery efficacy remains to be improved. In this study, IL10 nanoparticles were successfully prepared and then coated by a preactive platelet membrane. The ability to target and regulate macrophage polarization has been demonstrated, thereby regulating smooth muscle cell and endothelial cell functions. In vivo experiments were carried out in a carotid artery injury model and verified the above functions and the effect on inhibiting vascular restenosis. Immune regulation-based platelet membrane coated nanoparticle loaded with IL10 proved to be an excellent candidate for targeting vascular injury and holds promise as an innovative drug delivery system for suppressing vascular restenosis. |
| first_indexed | 2024-04-13T18:25:24Z |
| format | Article |
| id | doaj.art-2abeb08c4cca4a6eab191c5689430100 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-13T18:25:24Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-2abeb08c4cca4a6eab191c56894301002022-12-22T02:35:16ZengElsevieriScience2589-00422022-10-012510105147Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarizationFengshi Li0Zhihua Rong1Rui Zhang2Shuai Niu3Xiao Di4Leng Ni5Changwei Liu6Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People’s Republic of ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People’s Republic of ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People’s Republic of ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People’s Republic of ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People’s Republic of ChinaDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People’s Republic of China; Corresponding authorDepartment of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, People’s Republic of China; Corresponding authorSummary: Vascular restenosis is the main factor affecting the prognosis of angioplasty in cardiovascular diseases, and inflammation is a central link in the progression of restenosis. Previous research that applies interleukin 10 (IL10) nanoparticles can effectively regulate local inflammation, but their targeted delivery efficacy remains to be improved. In this study, IL10 nanoparticles were successfully prepared and then coated by a preactive platelet membrane. The ability to target and regulate macrophage polarization has been demonstrated, thereby regulating smooth muscle cell and endothelial cell functions. In vivo experiments were carried out in a carotid artery injury model and verified the above functions and the effect on inhibiting vascular restenosis. Immune regulation-based platelet membrane coated nanoparticle loaded with IL10 proved to be an excellent candidate for targeting vascular injury and holds promise as an innovative drug delivery system for suppressing vascular restenosis.http://www.sciencedirect.com/science/article/pii/S2589004222014195Drug delivery systemnanoparticlesimmune response |
| spellingShingle | Fengshi Li Zhihua Rong Rui Zhang Shuai Niu Xiao Di Leng Ni Changwei Liu Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization iScience Drug delivery system nanoparticles immune response |
| title | Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization |
| title_full | Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization |
| title_fullStr | Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization |
| title_full_unstemmed | Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization |
| title_short | Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization |
| title_sort | vascular restenosis reduction with platelet membrane coated nanoparticle directed m2 macrophage polarization |
| topic | Drug delivery system nanoparticles immune response |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222014195 |
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