Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder
Abstract Although functional and structural abnormalities in brain regions involved in the neurobiology of fear and anxiety have been observed in patients with social anxiety disorder (SAD), the findings have been heterogeneous due to small sample sizes, demographic confounders, and methodological d...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2022-01-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-01791-7 |
| _version_ | 1798016315036794880 |
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| author | Xun Zhang Xueling Suo Xun Yang Han Lai Nanfang Pan Min He Qingyuan Li Weihong Kuang Song Wang Qiyong Gong |
| author_facet | Xun Zhang Xueling Suo Xun Yang Han Lai Nanfang Pan Min He Qingyuan Li Weihong Kuang Song Wang Qiyong Gong |
| author_sort | Xun Zhang |
| collection | DOAJ |
| description | Abstract Although functional and structural abnormalities in brain regions involved in the neurobiology of fear and anxiety have been observed in patients with social anxiety disorder (SAD), the findings have been heterogeneous due to small sample sizes, demographic confounders, and methodological differences. Besides, multimodal neuroimaging studies on structural-functional deficits and couplings are rather scarce. Herein, we aimed to explore functional network anomalies in brain regions with structural deficits and the effects of structure-function couplings on the SAD diagnosis. High-resolution structural magnetic resonance imaging (MRI) and resting-state functional MRI images were obtained from 49 non-comorbid patients with SAD and 53 demography-matched healthy controls. Whole-brain voxel-based morphometry analysis was conducted to investigate structural alterations, which were subsequently used as seeds for the resting-state functional connectivity analysis. In addition, correlation and mediation analyses were performed to probe the potential roles of structural-functional deficits in SAD diagnosis. SAD patients had significant gray matter volume reductions in the bilateral putamen, right thalamus, and left parahippocampus. Besides, patients with SAD demonstrated widespread resting-state dysconnectivity in cortico-striato-thalamo-cerebellar circuitry. Moreover, dysconnectivity of the putamen with the cerebellum and the right thalamus with the middle temporal gyrus/supplementary motor area partially mediated the effects of putamen/thalamus atrophy on the SAD diagnosis. Our findings provide preliminary evidence for the involvement of structural and functional deficits in cortico-striato-thalamo-cerebellar circuitry in SAD, and may contribute to clarifying the underlying mechanisms of structure-function couplings for SAD. Therefore, they could offer insights into the neurobiological substrates of SAD. |
| first_indexed | 2024-04-11T15:48:54Z |
| format | Article |
| id | doaj.art-2ac070de7aef46008c9265372d5960f2 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-11T15:48:54Z |
| publishDate | 2022-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-2ac070de7aef46008c9265372d5960f22022-12-22T04:15:26ZengNature Publishing GroupTranslational Psychiatry2158-31882022-01-0112111110.1038/s41398-022-01791-7Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorderXun Zhang0Xueling Suo1Xun Yang2Han Lai3Nanfang Pan4Min He5Qingyuan Li6Weihong Kuang7Song Wang8Qiyong Gong9Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversitySchool of Public Affairs, Chongqing UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityDepartment of Psychiatry, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan UniversityAbstract Although functional and structural abnormalities in brain regions involved in the neurobiology of fear and anxiety have been observed in patients with social anxiety disorder (SAD), the findings have been heterogeneous due to small sample sizes, demographic confounders, and methodological differences. Besides, multimodal neuroimaging studies on structural-functional deficits and couplings are rather scarce. Herein, we aimed to explore functional network anomalies in brain regions with structural deficits and the effects of structure-function couplings on the SAD diagnosis. High-resolution structural magnetic resonance imaging (MRI) and resting-state functional MRI images were obtained from 49 non-comorbid patients with SAD and 53 demography-matched healthy controls. Whole-brain voxel-based morphometry analysis was conducted to investigate structural alterations, which were subsequently used as seeds for the resting-state functional connectivity analysis. In addition, correlation and mediation analyses were performed to probe the potential roles of structural-functional deficits in SAD diagnosis. SAD patients had significant gray matter volume reductions in the bilateral putamen, right thalamus, and left parahippocampus. Besides, patients with SAD demonstrated widespread resting-state dysconnectivity in cortico-striato-thalamo-cerebellar circuitry. Moreover, dysconnectivity of the putamen with the cerebellum and the right thalamus with the middle temporal gyrus/supplementary motor area partially mediated the effects of putamen/thalamus atrophy on the SAD diagnosis. Our findings provide preliminary evidence for the involvement of structural and functional deficits in cortico-striato-thalamo-cerebellar circuitry in SAD, and may contribute to clarifying the underlying mechanisms of structure-function couplings for SAD. Therefore, they could offer insights into the neurobiological substrates of SAD.https://doi.org/10.1038/s41398-022-01791-7 |
| spellingShingle | Xun Zhang Xueling Suo Xun Yang Han Lai Nanfang Pan Min He Qingyuan Li Weihong Kuang Song Wang Qiyong Gong Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder Translational Psychiatry |
| title | Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder |
| title_full | Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder |
| title_fullStr | Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder |
| title_full_unstemmed | Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder |
| title_short | Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder |
| title_sort | structural and functional deficits and couplings in the cortico striato thalamo cerebellar circuitry in social anxiety disorder |
| url | https://doi.org/10.1038/s41398-022-01791-7 |
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