Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb)

Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb)

Lead (Pb) exposure has adverse health effects and altered DNA methylation may contribute to Pb toxicity. LINE-1 is an interspersed repeated DNA that is used as a surrogate marker for estimating genomic DNA methylation levels, and GSTP1 is an isozyme that detoxifies xenobiotics like Pb, and its expre...

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Bibliographic Details
Main Authors: Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Haruya Toyomaki, Andrew Kataba, Hokuto Nakata, Kaampwe Muzandu, Chihiro Miyashita, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Epigenetics
Subjects:
blood lead
children
dna methylation
gstp1
line-1
Online Access:http://dx.doi.org/10.1080/15592294.2022.2123924

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