Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging
Previous studies have used magnetic resonance imaging (MRI) to quantify the fluid in the stomach and small intestine of children, and the stomach, small intestine and colon of adults. This is the first study to quantify fluid volumes and distribution using MRI in the paediatric colon. MRI datasets f...
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MDPI AG
2021-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/10/1729 |
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| author | Jan Goelen Benoni Alexander Haren Eranga Wijesinghe Emily Evans Gopal Pawar Richard D. Horniblow Hannah K. Batchelor |
| author_facet | Jan Goelen Benoni Alexander Haren Eranga Wijesinghe Emily Evans Gopal Pawar Richard D. Horniblow Hannah K. Batchelor |
| author_sort | Jan Goelen |
| collection | DOAJ |
| description | Previous studies have used magnetic resonance imaging (MRI) to quantify the fluid in the stomach and small intestine of children, and the stomach, small intestine and colon of adults. This is the first study to quantify fluid volumes and distribution using MRI in the paediatric colon. MRI datasets from 28 fasted (aged 0–15 years) and 18 fluid-fed (aged 10–16 years) paediatric participants were acquired during routine clinical care. A series of 2D- and 3D-based software protocols were used to measure colonic fluid volume and localisation. The paediatric colon contained a mean volume of 22.5 mL ± 41.3 mL fluid, (range 0–167.5 mL, median volume 0.80 mL) in 15.5 ± 17.5 discreet fluid pockets (median 12). The proportion of the fluid pockets larger than 1 mL was 9.6%, which contributed to 94.5% of the total fluid volume observed. No correlation was detected between all-ages and colonic fluid volume, nor was a difference in colonic fluid volumes observed based on sex, fed state or age group based on ICH-classifications. This study quantified fluid volumes within the paediatric colon, and these data will aid and accelerate the development of biorelevant tools to progress paediatric drug development for colon-targeting formulations. |
| first_indexed | 2024-03-10T06:16:02Z |
| format | Article |
| id | doaj.art-2ac288bd4d6a43ee9392c9fb8ae66a94 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T06:16:02Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-2ac288bd4d6a43ee9392c9fb8ae66a942023-11-22T19:40:29ZengMDPI AGPharmaceutics1999-49232021-10-011310172910.3390/pharmaceutics13101729Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance ImagingJan Goelen0Benoni Alexander1Haren Eranga Wijesinghe2Emily Evans3Gopal Pawar4Richard D. Horniblow5Hannah K. Batchelor6School of Pharmacy, Institute of Clinical Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKSchool of Biomedical Science, Institute of Clinical Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKDepartment of Radiology, University Hospital Coventry & Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UKDepartment of Radiology, University Hospital Coventry & Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UKSchool of Pharmacy, Institute of Clinical Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKSchool of Biomedical Science, Institute of Clinical Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UKStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UKPrevious studies have used magnetic resonance imaging (MRI) to quantify the fluid in the stomach and small intestine of children, and the stomach, small intestine and colon of adults. This is the first study to quantify fluid volumes and distribution using MRI in the paediatric colon. MRI datasets from 28 fasted (aged 0–15 years) and 18 fluid-fed (aged 10–16 years) paediatric participants were acquired during routine clinical care. A series of 2D- and 3D-based software protocols were used to measure colonic fluid volume and localisation. The paediatric colon contained a mean volume of 22.5 mL ± 41.3 mL fluid, (range 0–167.5 mL, median volume 0.80 mL) in 15.5 ± 17.5 discreet fluid pockets (median 12). The proportion of the fluid pockets larger than 1 mL was 9.6%, which contributed to 94.5% of the total fluid volume observed. No correlation was detected between all-ages and colonic fluid volume, nor was a difference in colonic fluid volumes observed based on sex, fed state or age group based on ICH-classifications. This study quantified fluid volumes within the paediatric colon, and these data will aid and accelerate the development of biorelevant tools to progress paediatric drug development for colon-targeting formulations.https://www.mdpi.com/1999-4923/13/10/1729intestinal fluidMRIpaediatricsbiorelevant dissolutionlarge bowelcolon |
| spellingShingle | Jan Goelen Benoni Alexander Haren Eranga Wijesinghe Emily Evans Gopal Pawar Richard D. Horniblow Hannah K. Batchelor Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging Pharmaceutics intestinal fluid MRI paediatrics biorelevant dissolution large bowel colon |
| title | Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging |
| title_full | Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging |
| title_fullStr | Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging |
| title_full_unstemmed | Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging |
| title_short | Quantification of Fluid Volume and Distribution in the Paediatric Colon via Magnetic Resonance Imaging |
| title_sort | quantification of fluid volume and distribution in the paediatric colon via magnetic resonance imaging |
| topic | intestinal fluid MRI paediatrics biorelevant dissolution large bowel colon |
| url | https://www.mdpi.com/1999-4923/13/10/1729 |
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