Β-crosslaps in knee osteoarthritis – assessment and rehabilitation
The bone turnover is important for the progression of osteoarthritis. The C-terminal telopeptide of type I collagen, β-CrossLaps (β-CTx) is considered as the first-choice bone resorption markers. Today, the biochemical markers have been associated with pain and disease severity in knee osteoarthrit...
| Автори: | , , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Romanian Association of Balneology, Editura Balneara
2024-03-01
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| Серія: | Balneo and PRM Research Journal |
| Предмети: | |
| Онлайн доступ: | https://bioclima.ro/Balneo673.pdf |
| _version_ | 1827295611603386368 |
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| author | Ovidiu-Florin Fugaru Mircea-Sebastian Șerbănescu Lorena Ivona Stefan Magdalena Rodica Trăistaru |
| author_facet | Ovidiu-Florin Fugaru Mircea-Sebastian Șerbănescu Lorena Ivona Stefan Magdalena Rodica Trăistaru |
| author_sort | Ovidiu-Florin Fugaru |
| collection | DOAJ |
| description | The bone turnover is important for the progression of osteoarthritis. The C-terminal telopeptide of type I collagen, β-CrossLaps (β-CTx) is considered as the first-choice bone resorption markers. Today, the biochemical markers have been associated with pain and disease severity in knee osteoarthritis (KOA) patients.
We studied the association between β-CTx and functional status in KOA patients, pre- and postrehabilitation program. The primary goals of our study are both to establish the correla-tion between the serum level of β-CTx and other parameters of clinical and functional status in KOA patients and to compare the CTX-I values before and after rehabilitation program. We re-spected the actual international management recommendations for KOA.
A total of 130 patients were randomly allocated into two distinct groups: Study Group (SG = 90 patients) performed 10 sessions of complete rehabilitation program (magnetodiaflux, transcuta-neous nerve stimulation, ultrasound and low intensity laser treatment, kinetic measures), and Control Group (CG = 40 patients) performed 10 sessions of kinetic program. Both programs were performed daily, 5 days/week, 2 weeks. Evaluation of patients was carried out in two stag-es - initial (T1) and after 3 months (T2).
Comparing the initial values with the final ones for β-CTx, we noticed a high significant differ-ence between initial and final values only in SG patients. For the both T1 and T2 moments, there was no a statistically significant difference between β-CTx values from the two groups. Analyz-ing the differences between the values of clinical parameters (Six Minutes Walking Test, Timed Up-and-Go test, walk cadence and Symmetry index in walk) obtained between the patients from the two groups, we noticed that, for the T2 moment, there was a statistically significant differ-ence between studied parameters, except walk cadence.
In the assessment of global KOA patient status (clinical and functional status in accordance with bone-cartilage interface dynamics), β-CTx has significant value and could be used for monitoring the individualized rehabilitation program. |
| first_indexed | 2024-04-24T14:23:21Z |
| format | Article |
| id | doaj.art-2ac2c83fe09d4d568f050495eda93cc1 |
| institution | Directory Open Access Journal |
| issn | 2734-8458 |
| language | English |
| last_indexed | 2024-04-24T14:23:21Z |
| publishDate | 2024-03-01 |
| publisher | Romanian Association of Balneology, Editura Balneara |
| record_format | Article |
| series | Balneo and PRM Research Journal |
| spelling | doaj.art-2ac2c83fe09d4d568f050495eda93cc12024-04-03T05:31:43ZengRomanian Association of Balneology, Editura BalnearaBalneo and PRM Research Journal2734-84582024-03-0115167310.12680/balneo.2024.673Β-crosslaps in knee osteoarthritis – assessment and rehabilitationOvidiu-Florin Fugaru0Mircea-Sebastian Șerbănescu 1Lorena Ivona Stefan2Magdalena Rodica Trăistaru 3Doctoral School, University of Medicine and Pharmacy of Craiova, RomaniaDepartment of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania; Filantropia Clinical Municipal Hospital CraiovaCenter of Physical Therapy and Rehabilitation, “Dunarea de Jos” University of Galati, 800008 Galati, RomaniaFilantropia Clinical Municipal Hospital Craiova; Department of Physical and Rehabilitation Medicine, Nursing Faculty, University of Medicine and Pharmacy of Craiova, RomaniaThe bone turnover is important for the progression of osteoarthritis. The C-terminal telopeptide of type I collagen, β-CrossLaps (β-CTx) is considered as the first-choice bone resorption markers. Today, the biochemical markers have been associated with pain and disease severity in knee osteoarthritis (KOA) patients. We studied the association between β-CTx and functional status in KOA patients, pre- and postrehabilitation program. The primary goals of our study are both to establish the correla-tion between the serum level of β-CTx and other parameters of clinical and functional status in KOA patients and to compare the CTX-I values before and after rehabilitation program. We re-spected the actual international management recommendations for KOA. A total of 130 patients were randomly allocated into two distinct groups: Study Group (SG = 90 patients) performed 10 sessions of complete rehabilitation program (magnetodiaflux, transcuta-neous nerve stimulation, ultrasound and low intensity laser treatment, kinetic measures), and Control Group (CG = 40 patients) performed 10 sessions of kinetic program. Both programs were performed daily, 5 days/week, 2 weeks. Evaluation of patients was carried out in two stag-es - initial (T1) and after 3 months (T2). Comparing the initial values with the final ones for β-CTx, we noticed a high significant differ-ence between initial and final values only in SG patients. For the both T1 and T2 moments, there was no a statistically significant difference between β-CTx values from the two groups. Analyz-ing the differences between the values of clinical parameters (Six Minutes Walking Test, Timed Up-and-Go test, walk cadence and Symmetry index in walk) obtained between the patients from the two groups, we noticed that, for the T2 moment, there was a statistically significant differ-ence between studied parameters, except walk cadence. In the assessment of global KOA patient status (clinical and functional status in accordance with bone-cartilage interface dynamics), β-CTx has significant value and could be used for monitoring the individualized rehabilitation program.https://bioclima.ro/Balneo673.pdfβ-crosslapskneeosteoarthritisrehabilitation program |
| spellingShingle | Ovidiu-Florin Fugaru Mircea-Sebastian Șerbănescu Lorena Ivona Stefan Magdalena Rodica Trăistaru Β-crosslaps in knee osteoarthritis – assessment and rehabilitation Balneo and PRM Research Journal β-crosslaps knee osteoarthritis rehabilitation program |
| title | Β-crosslaps in knee osteoarthritis – assessment and rehabilitation |
| title_full | Β-crosslaps in knee osteoarthritis – assessment and rehabilitation |
| title_fullStr | Β-crosslaps in knee osteoarthritis – assessment and rehabilitation |
| title_full_unstemmed | Β-crosslaps in knee osteoarthritis – assessment and rehabilitation |
| title_short | Β-crosslaps in knee osteoarthritis – assessment and rehabilitation |
| title_sort | β crosslaps in knee osteoarthritis assessment and rehabilitation |
| topic | β-crosslaps knee osteoarthritis rehabilitation program |
| url | https://bioclima.ro/Balneo673.pdf |
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