The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells
Phycocyanin, a type of functional food colorant, is shown to have a potent anti-cancer property. Non-small cell lung cancer (NSCLC) is one of the most aggressive form of cancers with few effective therapeutic options. Previous studies have demonstrated that phycocyanin exerts a growth inhibitory eff...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/6/178 |
| _version_ | 1818014907030831104 |
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| author | Shuai Hao Yan Yan Shuang Li Lei Zhao Chan Zhang Liyun Liu Chengtao Wang |
| author_facet | Shuai Hao Yan Yan Shuang Li Lei Zhao Chan Zhang Liyun Liu Chengtao Wang |
| author_sort | Shuai Hao |
| collection | DOAJ |
| description | Phycocyanin, a type of functional food colorant, is shown to have a potent anti-cancer property. Non-small cell lung cancer (NSCLC) is one of the most aggressive form of cancers with few effective therapeutic options. Previous studies have demonstrated that phycocyanin exerts a growth inhibitory effect on NSCLC A549 cells. However, its biological function and underlying regulatory mechanism on other cells still remain unknown. Here, we investigated the in vitro function of phycocyanin on three typical NSCLC cell lines, NCI-H1299, NCI-H460, and LTEP-A2, for the first time. The results showed that phycocyanin could significantly induce apoptosis, cell cycle arrest, as well as suppress cell migration, proliferation, and the colony formation ability of NSCLC cells through regulating multiple key genes. Strikingly, phycocyanin was discovered to affect the cell phenotype through regulating the NF-κB signaling of NSCLC cells. Our findings demonstrated the anti-neoplastic function of phycocyanin and provided valuable information for the regulation of phycocyanin in NSCLC cells. |
| first_indexed | 2024-04-14T06:51:09Z |
| format | Article |
| id | doaj.art-2ac30ccd5ffe4352ad739129f93aa790 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T06:51:09Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-2ac30ccd5ffe4352ad739129f93aa7902022-12-22T02:07:02ZengMDPI AGMarine Drugs1660-33972018-05-0116617810.3390/md16060178md16060178The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer CellsShuai Hao0Yan Yan1Shuang Li2Lei Zhao3Chan Zhang4Liyun Liu5Chengtao Wang6Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, ChinaPhycocyanin, a type of functional food colorant, is shown to have a potent anti-cancer property. Non-small cell lung cancer (NSCLC) is one of the most aggressive form of cancers with few effective therapeutic options. Previous studies have demonstrated that phycocyanin exerts a growth inhibitory effect on NSCLC A549 cells. However, its biological function and underlying regulatory mechanism on other cells still remain unknown. Here, we investigated the in vitro function of phycocyanin on three typical NSCLC cell lines, NCI-H1299, NCI-H460, and LTEP-A2, for the first time. The results showed that phycocyanin could significantly induce apoptosis, cell cycle arrest, as well as suppress cell migration, proliferation, and the colony formation ability of NSCLC cells through regulating multiple key genes. Strikingly, phycocyanin was discovered to affect the cell phenotype through regulating the NF-κB signaling of NSCLC cells. Our findings demonstrated the anti-neoplastic function of phycocyanin and provided valuable information for the regulation of phycocyanin in NSCLC cells.http://www.mdpi.com/1660-3397/16/6/178phycocyaninnon-small cell lung cancerproliferationapoptosisNF-κB signaling |
| spellingShingle | Shuai Hao Yan Yan Shuang Li Lei Zhao Chan Zhang Liyun Liu Chengtao Wang The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells Marine Drugs phycocyanin non-small cell lung cancer proliferation apoptosis NF-κB signaling |
| title | The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells |
| title_full | The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells |
| title_fullStr | The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells |
| title_full_unstemmed | The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells |
| title_short | The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells |
| title_sort | in vitro anti tumor activity of phycocyanin against non small cell lung cancer cells |
| topic | phycocyanin non-small cell lung cancer proliferation apoptosis NF-κB signaling |
| url | http://www.mdpi.com/1660-3397/16/6/178 |
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