Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study

Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study

Introduction: Treatment of paediatric heart failure is based on paradigms extensively tested in the adult population assuming similar underlying pathophysiological mechanisms. Angiotensin converting enzyme inhibitors (ACEI) like enalapril are one of the cornerstones of treatment and commonly used of...

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Main Authors: Milica Bajcetic, Saskia N. de Wildt, Michiel Dalinghaus, Jörg Breitkreutz, Ingrid Klingmann, Florian B. Lagler, Anne Keatley-Clarke, Johannes MPJ. Breur, Christoph Male, Ida Jovanovic, Andras Szatmári, László Ablonczy, Bjoern B. Burckhardt, Willi Cawello, Karl Kleine, Emina Obarcanin, Lucie Spatenkova, Vanessa Swoboda, Marijke van der Meulen, Peter Wagner, Jennifer Walsh, Stephanie Läer
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865419300456

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