Poorly differentiated monophasic synovial sarcoma of the mediastinum
Poorly differentiated synovial sarcoma is a diagnostically challenging neoplasm. Most commonly they occur in the soft tissue of the extremities and are rare in the mediastinum. They can be indistinguishable from other "round cell tumors" based on the morphology alone or at times by immunoh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=2;spage=384;epage=387;aulast=Arafah |
| _version_ | 1818109564639248384 |
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| author | Maha Arafah Shaesta N Zaidi |
| author_facet | Maha Arafah Shaesta N Zaidi |
| author_sort | Maha Arafah |
| collection | DOAJ |
| description | Poorly differentiated synovial sarcoma is a diagnostically challenging neoplasm. Most commonly they occur in the soft tissue of the extremities and are rare in the mediastinum. They can be indistinguishable from other "round cell tumors" based on the morphology alone or at times by immunohistochemical studies. Here in, we report an extremely rare case of metastatic poorly differentiated monophasic synovial sarcoma of the mediastinum without a known primary in a 30-year-old man. The imaging studies on admission showed 10 × 9.5 cm anterior mediastinal mass with multiple nodules in the lung and pleura along with multiple enlarged mediastinal and axillary lymph nodes. Histopathologic and immunohistochemical analysis supported the diagnosis of poorly differentiated synovial sarcoma, which was further confirmed by molecular genetic analysis. |
| first_indexed | 2024-12-11T02:33:16Z |
| format | Article |
| id | doaj.art-2ac54e8b9f23489aaf3d2e0f1df94e98 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-11T02:33:16Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-2ac54e8b9f23489aaf3d2e0f1df94e982022-12-22T01:23:47ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292011-01-0154238438710.4103/0377-4929.81650Poorly differentiated monophasic synovial sarcoma of the mediastinumMaha ArafahShaesta N ZaidiPoorly differentiated synovial sarcoma is a diagnostically challenging neoplasm. Most commonly they occur in the soft tissue of the extremities and are rare in the mediastinum. They can be indistinguishable from other "round cell tumors" based on the morphology alone or at times by immunohistochemical studies. Here in, we report an extremely rare case of metastatic poorly differentiated monophasic synovial sarcoma of the mediastinum without a known primary in a 30-year-old man. The imaging studies on admission showed 10 × 9.5 cm anterior mediastinal mass with multiple nodules in the lung and pleura along with multiple enlarged mediastinal and axillary lymph nodes. Histopathologic and immunohistochemical analysis supported the diagnosis of poorly differentiated synovial sarcoma, which was further confirmed by molecular genetic analysis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=2;spage=384;epage=387;aulast=ArafahImmunohistochemistrymediastinumsynovial sarcoma |
| spellingShingle | Maha Arafah Shaesta N Zaidi Poorly differentiated monophasic synovial sarcoma of the mediastinum Indian Journal of Pathology and Microbiology Immunohistochemistry mediastinum synovial sarcoma |
| title | Poorly differentiated monophasic synovial sarcoma of the mediastinum |
| title_full | Poorly differentiated monophasic synovial sarcoma of the mediastinum |
| title_fullStr | Poorly differentiated monophasic synovial sarcoma of the mediastinum |
| title_full_unstemmed | Poorly differentiated monophasic synovial sarcoma of the mediastinum |
| title_short | Poorly differentiated monophasic synovial sarcoma of the mediastinum |
| title_sort | poorly differentiated monophasic synovial sarcoma of the mediastinum |
| topic | Immunohistochemistry mediastinum synovial sarcoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=2;spage=384;epage=387;aulast=Arafah |
| work_keys_str_mv | AT mahaarafah poorlydifferentiatedmonophasicsynovialsarcomaofthemediastinum AT shaestanzaidi poorlydifferentiatedmonophasicsynovialsarcomaofthemediastinum |