The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosis
Cognitive deficits limit psychosocial functioning in schizophrenia. For many patients, cognitive remediation approaches have yielded encouraging results. Nevertheless, therapeutic response is variable, and outcome studies consistently identify individuals who respond minimally to these interventions...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00142/full |
| _version_ | 1818523355623456768 |
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| author | Melissa A Tarasenko Melissa A Tarasenko Neal R Swerdlow Scott eMakeig David L Braff Gregory A Light Gregory A Light |
| author_facet | Melissa A Tarasenko Melissa A Tarasenko Neal R Swerdlow Scott eMakeig David L Braff Gregory A Light Gregory A Light |
| author_sort | Melissa A Tarasenko |
| collection | DOAJ |
| description | Cognitive deficits limit psychosocial functioning in schizophrenia. For many patients, cognitive remediation approaches have yielded encouraging results. Nevertheless, therapeutic response is variable, and outcome studies consistently identify individuals who respond minimally to these interventions. Biomarkers that can assist in identifying patients likely to benefit from particular forms of cognitive remediation are needed. Here we describe an event-related potential (ERP) biomarker – the auditory brainstem response to complex sounds (cABR) – that appears to be particularly well-suited for predicting response to at least one form of cognitive remediation that targets auditory information processing. Uniquely, the cABR quantifies the fidelity of sound encoded at the level of the brainstem and midbrain. This ERP biomarker has revealed auditory processing abnormalities in various neurodevelopmental disorders, correlates with functioning across several cognitive domains, and appears to be responsive to targeted auditory training. We present preliminary cABR data from 18 schizophrenia patients and propose further investigation of this biomarker for predicting and tracking response to cognitive interventions. |
| first_indexed | 2024-12-11T05:43:57Z |
| format | Article |
| id | doaj.art-2ac56456f67f4cb3a1b77c55b19544e8 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T05:43:57Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-2ac56456f67f4cb3a1b77c55b19544e82022-12-22T01:19:02ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402014-10-01510.3389/fpsyt.2014.00142111783The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosisMelissa A Tarasenko0Melissa A Tarasenko1Neal R Swerdlow2Scott eMakeig3David L Braff4Gregory A Light5Gregory A Light6VA San Diego Healthcare SystemUniversity of California, San DiegoUniversity of California, San DiegoUniversity of California, San DiegoUniversity of California, San DiegoUniversity of California, San DiegoVA San Diego Healthcare SystemCognitive deficits limit psychosocial functioning in schizophrenia. For many patients, cognitive remediation approaches have yielded encouraging results. Nevertheless, therapeutic response is variable, and outcome studies consistently identify individuals who respond minimally to these interventions. Biomarkers that can assist in identifying patients likely to benefit from particular forms of cognitive remediation are needed. Here we describe an event-related potential (ERP) biomarker – the auditory brainstem response to complex sounds (cABR) – that appears to be particularly well-suited for predicting response to at least one form of cognitive remediation that targets auditory information processing. Uniquely, the cABR quantifies the fidelity of sound encoded at the level of the brainstem and midbrain. This ERP biomarker has revealed auditory processing abnormalities in various neurodevelopmental disorders, correlates with functioning across several cognitive domains, and appears to be responsive to targeted auditory training. We present preliminary cABR data from 18 schizophrenia patients and propose further investigation of this biomarker for predicting and tracking response to cognitive interventions.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00142/fullSchizophreniaEEGpsychosisbiomarkerscognitive remediationcABR |
| spellingShingle | Melissa A Tarasenko Melissa A Tarasenko Neal R Swerdlow Scott eMakeig David L Braff Gregory A Light Gregory A Light The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosis Frontiers in Psychiatry Schizophrenia EEG psychosis biomarkers cognitive remediation cABR |
| title | The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosis |
| title_full | The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosis |
| title_fullStr | The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosis |
| title_full_unstemmed | The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosis |
| title_short | The auditory brainstem response to complex sounds: a potential biomarker for guiding treatment of psychosis |
| title_sort | auditory brainstem response to complex sounds a potential biomarker for guiding treatment of psychosis |
| topic | Schizophrenia EEG psychosis biomarkers cognitive remediation cABR |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00142/full |
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