Potential Effects of Oral Isotretinoin on Growth Plate and Height
Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide. Isotretinoin is a synthetic vitamin A derivative drug effectiv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Endocrines |
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| Online Access: | https://www.mdpi.com/2673-396X/4/2/23 |
| _version_ | 1797595086710636544 |
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| author | Adriane A. Cardoso-Demartini Cesar Luiz Boguszewski Margaret C. S. Boguszewski |
| author_facet | Adriane A. Cardoso-Demartini Cesar Luiz Boguszewski Margaret C. S. Boguszewski |
| author_sort | Adriane A. Cardoso-Demartini |
| collection | DOAJ |
| description | Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide. Isotretinoin is a synthetic vitamin A derivative drug effective and is widely employed for the treatment of moderate and severe acne vulgaris. Premature epiphyseal closure has been reported in patients with neuroblastoma treated with high doses of isotretinoin as well as in patients with acne receiving lower doses. Although the mechanisms for these effects are not clear, it has been suggested that isotretinoin may have a negative impact on the GH-IGF-I axis, leading to a reduction in IGF-I and IGFBP3 serum levels. Although many of the isotretinoin adverse effects in pediatric patients are transient, premature epiphyseal closure and bone abnormalities can lead to transient abnormalities and permanent deformities with a negative impact on longitudinal growth and final height. The aim of this study was to review the potential effects of oral isotretinoin on the growth plate and growth during childhood and adolescence. |
| first_indexed | 2024-03-11T02:31:28Z |
| format | Article |
| id | doaj.art-2ac8cf171dcb462091c6aea4fa814c9c |
| institution | Directory Open Access Journal |
| issn | 2673-396X |
| language | English |
| last_indexed | 2024-03-11T02:31:28Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Endocrines |
| spelling | doaj.art-2ac8cf171dcb462091c6aea4fa814c9c2023-11-18T10:10:33ZengMDPI AGEndocrines2673-396X2023-04-014228129210.3390/endocrines4020023Potential Effects of Oral Isotretinoin on Growth Plate and HeightAdriane A. Cardoso-Demartini0Cesar Luiz Boguszewski1Margaret C. S. Boguszewski2Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba 80060-240, PR, BrazilDepartment of Internal Medicine, Endocrine Division (SEMPR), Hospital de Clínicas, Universidade Federal do Paraná, Curitiba 80030-110, PR, BrazilDepartment of Pediatrics, Universidade Federal do Paraná, Curitiba 80030-110, PR, BrazilLongitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide. Isotretinoin is a synthetic vitamin A derivative drug effective and is widely employed for the treatment of moderate and severe acne vulgaris. Premature epiphyseal closure has been reported in patients with neuroblastoma treated with high doses of isotretinoin as well as in patients with acne receiving lower doses. Although the mechanisms for these effects are not clear, it has been suggested that isotretinoin may have a negative impact on the GH-IGF-I axis, leading to a reduction in IGF-I and IGFBP3 serum levels. Although many of the isotretinoin adverse effects in pediatric patients are transient, premature epiphyseal closure and bone abnormalities can lead to transient abnormalities and permanent deformities with a negative impact on longitudinal growth and final height. The aim of this study was to review the potential effects of oral isotretinoin on the growth plate and growth during childhood and adolescence.https://www.mdpi.com/2673-396X/4/2/23isotretinoinacnevitamin Aretinoidgrowth |
| spellingShingle | Adriane A. Cardoso-Demartini Cesar Luiz Boguszewski Margaret C. S. Boguszewski Potential Effects of Oral Isotretinoin on Growth Plate and Height Endocrines isotretinoin acne vitamin A retinoid growth |
| title | Potential Effects of Oral Isotretinoin on Growth Plate and Height |
| title_full | Potential Effects of Oral Isotretinoin on Growth Plate and Height |
| title_fullStr | Potential Effects of Oral Isotretinoin on Growth Plate and Height |
| title_full_unstemmed | Potential Effects of Oral Isotretinoin on Growth Plate and Height |
| title_short | Potential Effects of Oral Isotretinoin on Growth Plate and Height |
| title_sort | potential effects of oral isotretinoin on growth plate and height |
| topic | isotretinoin acne vitamin A retinoid growth |
| url | https://www.mdpi.com/2673-396X/4/2/23 |
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