Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Clima...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2021-08-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000609&tlng=en |
| _version_ | 1818977255998619648 |
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| author | W. Corozolla V.H.S. Zago F.A.L. Marson A.M.H. de Avila P.D.P. Costa L.S. Teixeira F. Dalpino E.C. de Faria |
| author_facet | W. Corozolla V.H.S. Zago F.A.L. Marson A.M.H. de Avila P.D.P. Costa L.S. Teixeira F. Dalpino E.C. de Faria |
| author_sort | W. Corozolla |
| collection | DOAJ |
| description | In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime. |
| first_indexed | 2024-12-20T16:24:51Z |
| format | Article |
| id | doaj.art-2ac9c9be8b7744d2b86780fab1c947d0 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-20T16:24:51Z |
| publishDate | 2021-08-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-2ac9c9be8b7744d2b86780fab1c947d02022-12-21T19:33:28ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2021-08-01541010.1590/1414-431x2021e11035Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year studyW. Corozollahttps://orcid.org/0000-0002-6526-7828V.H.S. Zagohttps://orcid.org/0000-0003-2488-0199F.A.L. Marsonhttps://orcid.org/0000-0003-4955-4234A.M.H. de Avilahttps://orcid.org/0000-0002-6801-8528P.D.P. Costahttps://orcid.org/0000-0002-1534-5744L.S. Teixeirahttps://orcid.org/0000-0001-7146-9074F. Dalpinohttps://orcid.org/0000-0002-0091-0886E.C. de Fariahttps://orcid.org/0000-0002-5208-1274In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000609&tlng=enAtherosclerotic cardiovascular diseaseClimatic variationsLipoproteinsSeasonality |
| spellingShingle | W. Corozolla V.H.S. Zago F.A.L. Marson A.M.H. de Avila P.D.P. Costa L.S. Teixeira F. Dalpino E.C. de Faria Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study Brazilian Journal of Medical and Biological Research Atherosclerotic cardiovascular disease Climatic variations Lipoproteins Seasonality |
| title | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
| title_full | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
| title_fullStr | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
| title_full_unstemmed | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
| title_short | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
| title_sort | associations of plasma lipids lipoproteins and cardiovascular outcomes with climatic variations in a large brazilian population of campinas sao paulo state an eight year study |
| topic | Atherosclerotic cardiovascular disease Climatic variations Lipoproteins Seasonality |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000609&tlng=en |
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