Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review.
<h4>Aim</h4>Long acting injectable (LAI) antipsychotics are an alternative to oral antipsychotic (OAP) treatment and may be beneficial for patients in the early stages of schizophrenia. This study aims to provide a comprehensive review on the efficacy of first-generation and second-gener...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0267808 |
| _version_ | 1818545720169332736 |
|---|---|
| author | Lulu Lian David D Kim Ric M Procyshyn Diana Cázares William G Honer Alasdair M Barr |
| author_facet | Lulu Lian David D Kim Ric M Procyshyn Diana Cázares William G Honer Alasdair M Barr |
| author_sort | Lulu Lian |
| collection | DOAJ |
| description | <h4>Aim</h4>Long acting injectable (LAI) antipsychotics are an alternative to oral antipsychotic (OAP) treatment and may be beneficial for patients in the early stages of schizophrenia. This study aims to provide a comprehensive review on the efficacy of first-generation and second-generation LAI antipsychotics in recent-onset, first-episode, and early psychosis patients.<h4>Methods</h4>MEDLINE, EMBASE, PsycINFO, and Web of Science Core databases were used to search for studies that used LAIs in early psychosis patients. Studies published up to 06 Jun 2019 were included with no language restrictions applied. Inclusion criteria were a diagnosis of schizophrenia or related disorder, where patients were in their first episode or had a duration of illness ≤5 years.<h4>Results</h4>33 studies were included: 8 RCTs, 4 post-hoc analyses, 2 case reports, and 19 naturalistic studies. The majority of studies evaluated risperidone LAIs (N = 14) and paliperidone palmitate (N = 10), while the remainder investigated fluphenazine decanoate (N = 3), flupentixol decanoate (N = 2), and aripiprazole (N = 1). Two studies did not specify the LAI formulation used, and one cohort study compared the efficacy of multiple different LAI formulations.<h4>Conclusions</h4>While the majority of data is based on naturalistic studies investigating risperidone LAIs or paliperidone palmitate, LAIs may be an effective treatment for early psychosis patients in terms of adherence, relapse reduction, and symptom improvements. There is still a need to conduct more high quality RCTs that investigate the efficacy of different LAI formulations in early psychosis patients. |
| first_indexed | 2024-12-12T07:43:44Z |
| format | Article |
| id | doaj.art-2ac9d4a6062d469ab62824bf7ce22471 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T07:43:44Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2ac9d4a6062d469ab62824bf7ce224712022-12-22T00:32:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01174e026780810.1371/journal.pone.0267808Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review.Lulu LianDavid D KimRic M ProcyshynDiana CázaresWilliam G HonerAlasdair M Barr<h4>Aim</h4>Long acting injectable (LAI) antipsychotics are an alternative to oral antipsychotic (OAP) treatment and may be beneficial for patients in the early stages of schizophrenia. This study aims to provide a comprehensive review on the efficacy of first-generation and second-generation LAI antipsychotics in recent-onset, first-episode, and early psychosis patients.<h4>Methods</h4>MEDLINE, EMBASE, PsycINFO, and Web of Science Core databases were used to search for studies that used LAIs in early psychosis patients. Studies published up to 06 Jun 2019 were included with no language restrictions applied. Inclusion criteria were a diagnosis of schizophrenia or related disorder, where patients were in their first episode or had a duration of illness ≤5 years.<h4>Results</h4>33 studies were included: 8 RCTs, 4 post-hoc analyses, 2 case reports, and 19 naturalistic studies. The majority of studies evaluated risperidone LAIs (N = 14) and paliperidone palmitate (N = 10), while the remainder investigated fluphenazine decanoate (N = 3), flupentixol decanoate (N = 2), and aripiprazole (N = 1). Two studies did not specify the LAI formulation used, and one cohort study compared the efficacy of multiple different LAI formulations.<h4>Conclusions</h4>While the majority of data is based on naturalistic studies investigating risperidone LAIs or paliperidone palmitate, LAIs may be an effective treatment for early psychosis patients in terms of adherence, relapse reduction, and symptom improvements. There is still a need to conduct more high quality RCTs that investigate the efficacy of different LAI formulations in early psychosis patients.https://doi.org/10.1371/journal.pone.0267808 |
| spellingShingle | Lulu Lian David D Kim Ric M Procyshyn Diana Cázares William G Honer Alasdair M Barr Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review. PLoS ONE |
| title | Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review. |
| title_full | Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review. |
| title_fullStr | Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review. |
| title_full_unstemmed | Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review. |
| title_short | Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review. |
| title_sort | long acting injectable antipsychotics for early psychosis a comprehensive systematic review |
| url | https://doi.org/10.1371/journal.pone.0267808 |
| work_keys_str_mv | AT lululian longactinginjectableantipsychoticsforearlypsychosisacomprehensivesystematicreview AT daviddkim longactinginjectableantipsychoticsforearlypsychosisacomprehensivesystematicreview AT ricmprocyshyn longactinginjectableantipsychoticsforearlypsychosisacomprehensivesystematicreview AT dianacazares longactinginjectableantipsychoticsforearlypsychosisacomprehensivesystematicreview AT williamghoner longactinginjectableantipsychoticsforearlypsychosisacomprehensivesystematicreview AT alasdairmbarr longactinginjectableantipsychoticsforearlypsychosisacomprehensivesystematicreview |