Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance
Acetyl-CoA carboxylase (ACCase: EC 6.4.1.2) is one of the essential biotins containing enzymes required by plants for fatty acid synthesis and elongation. The unique enzyme is present in its homomeric form in all the Gramineae family, making it a suitable target for developing herbicides selectively...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Agronomy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fagro.2023.1218824/full |
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| author | Bikash Kumar Rajak Priyanka Rani Pranabesh Mandal Rajender Singh Chhokar Nitesh Singh Durg Vijay Singh |
| author_facet | Bikash Kumar Rajak Priyanka Rani Pranabesh Mandal Rajender Singh Chhokar Nitesh Singh Durg Vijay Singh |
| author_sort | Bikash Kumar Rajak |
| collection | DOAJ |
| description | Acetyl-CoA carboxylase (ACCase: EC 6.4.1.2) is one of the essential biotins containing enzymes required by plants for fatty acid synthesis and elongation. The unique enzyme is present in its homomeric form in all the Gramineae family, making it a suitable target for developing herbicides selectively against weeds of the Gramineae family. One such example is infestation of Phalaris minor in winter wheat crop fields, where aryloxyphenoxypropionates (FOP); cyclohexanediones (DIM) and phenyl pyrazoline (DEN) group of ACCase inhibiting herbicides are used. However, the increasing number of ACCase herbicide resistant weed populations has compelled agro-scientists to seek varied possibilities for weed control, through Integrated Weed Management (IWM) strategies. Developing new potential herbicides to regain sensitivity in weeds could be an approach to weed control. The current advancement in computational techniques could be of aid in developing new herbicide-like molecules by exploring the genomics, proteomics and structural details of catalytic sites of herbicide action in crops as well as weeds. |
| first_indexed | 2024-03-12T22:44:56Z |
| format | Article |
| id | doaj.art-2aca2fbe440841d9943b0bb2382fec9e |
| institution | Directory Open Access Journal |
| issn | 2673-3218 |
| language | English |
| last_indexed | 2024-03-12T22:44:56Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Agronomy |
| spelling | doaj.art-2aca2fbe440841d9943b0bb2382fec9e2023-07-21T07:53:33ZengFrontiers Media S.A.Frontiers in Agronomy2673-32182023-07-01510.3389/fagro.2023.12188241218824Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistanceBikash Kumar Rajak0Priyanka Rani1Pranabesh Mandal2Rajender Singh Chhokar3Nitesh Singh4Durg Vijay Singh5Molecular Modelling and Computer-Aided Drug Discovery Laboratory, Department of Bioinformatics, School of Earth, Biological and Environmental Sciences, Central University of South Bihar, Gaya, IndiaMolecular Modelling and Computer-Aided Drug Discovery Laboratory, Department of Bioinformatics, School of Earth, Biological and Environmental Sciences, Central University of South Bihar, Gaya, IndiaMolecular Modelling and Computer-Aided Drug Discovery Laboratory, Department of Bioinformatics, School of Earth, Biological and Environmental Sciences, Central University of South Bihar, Gaya, IndiaIndian Council of Agricultural Research-Indian Institute of Wheat and Barley Research (ICAR-IIWBR), Karnal, IndiaDepartment of Plant-Pathology, Faculty of Agricultural Sciences, Shree Guru Gobind Singh Tricentenary University, Gurgaon, IndiaMolecular Modelling and Computer-Aided Drug Discovery Laboratory, Department of Bioinformatics, School of Earth, Biological and Environmental Sciences, Central University of South Bihar, Gaya, IndiaAcetyl-CoA carboxylase (ACCase: EC 6.4.1.2) is one of the essential biotins containing enzymes required by plants for fatty acid synthesis and elongation. The unique enzyme is present in its homomeric form in all the Gramineae family, making it a suitable target for developing herbicides selectively against weeds of the Gramineae family. One such example is infestation of Phalaris minor in winter wheat crop fields, where aryloxyphenoxypropionates (FOP); cyclohexanediones (DIM) and phenyl pyrazoline (DEN) group of ACCase inhibiting herbicides are used. However, the increasing number of ACCase herbicide resistant weed populations has compelled agro-scientists to seek varied possibilities for weed control, through Integrated Weed Management (IWM) strategies. Developing new potential herbicides to regain sensitivity in weeds could be an approach to weed control. The current advancement in computational techniques could be of aid in developing new herbicide-like molecules by exploring the genomics, proteomics and structural details of catalytic sites of herbicide action in crops as well as weeds.https://www.frontiersin.org/articles/10.3389/fagro.2023.1218824/fullacetyl-CoA carboxylase (ACCase)carboxyl transferase (CT) domainmutationherbicide resistancerational drug discoverysafeners |
| spellingShingle | Bikash Kumar Rajak Priyanka Rani Pranabesh Mandal Rajender Singh Chhokar Nitesh Singh Durg Vijay Singh Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance Frontiers in Agronomy acetyl-CoA carboxylase (ACCase) carboxyl transferase (CT) domain mutation herbicide resistance rational drug discovery safeners |
| title | Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance |
| title_full | Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance |
| title_fullStr | Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance |
| title_full_unstemmed | Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance |
| title_short | Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance |
| title_sort | emerging possibilities in the advancement of herbicides to combat acetyl coa carboxylase inhibitor resistance |
| topic | acetyl-CoA carboxylase (ACCase) carboxyl transferase (CT) domain mutation herbicide resistance rational drug discovery safeners |
| url | https://www.frontiersin.org/articles/10.3389/fagro.2023.1218824/full |
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