Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease
Emerging research indicates interruptions in the wiring organization of the brain network in Mild cognitive impairment (MCI) and Alzheimer's disease (AD). Due to the important role of rich-club organization in distinguishing abnormalities of AD patients and the close relationship between struct...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00053/full |
| _version_ | 1818517298736005120 |
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| author | Rui Cao Xin Wang Yuan Gao Ting Li Hui Zhang Waqar Hussain Yunyan Xie Jing Wang Bin Wang Jie Xiang |
| author_facet | Rui Cao Xin Wang Yuan Gao Ting Li Hui Zhang Waqar Hussain Yunyan Xie Jing Wang Bin Wang Jie Xiang |
| author_sort | Rui Cao |
| collection | DOAJ |
| description | Emerging research indicates interruptions in the wiring organization of the brain network in Mild cognitive impairment (MCI) and Alzheimer's disease (AD). Due to the important role of rich-club organization in distinguishing abnormalities of AD patients and the close relationship between structural connectivity (SC) and functional connectivity (FC), our study examined whether changes in SC-FC coupling and the relationship with abnormal rich-club organizations during the development of diseases may contribute to the pathophysiology of AD. Structural diffusion-tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) were performed in 38 normal controls (NCs), 40 MCI patients and 19 AD patients. Measures of the rich-club structure and its role in global structural–functional coupling were administered. Our study found decreased levels of feeder and local connectivity in MCI and AD patients, which were the main contributing factors to the lower efficiency of the brain structural network. Another important finding was that we have more accurately characterized the changing pattern of functional brain dynamics. The enhanced coupling between SC and FC in MCI and AD patients might be due to disruptions in optimal structural organization. More interestingly, we also found increases in the SC-FC coupling for feeder and local connections in MCI and AD patients. SC-FC coupling also showed significant differences between MCI and AD patients, mainly between the abnormal feeder connections. The connection density and coupling strength were significantly correlated with clinical metrics in patients. The present findings enhanced our understanding of the neurophysiologic mechanisms associated with MCI and AD. |
| first_indexed | 2024-12-11T00:54:24Z |
| format | Article |
| id | doaj.art-2aca442b5ee1440d9f439ad499290721 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T00:54:24Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-2aca442b5ee1440d9f439ad4992907212022-12-22T01:26:31ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-02-011110.3389/fneur.2020.00053474314Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's DiseaseRui Cao0Xin Wang1Yuan Gao2Ting Li3Hui Zhang4Waqar Hussain5Yunyan Xie6Jing Wang7Bin Wang8Jie Xiang9College of Software, Taiyuan University of Technology, Taiyuan, ChinaCollege of Information and Computer, Taiyuan University of Technology, Taiyuan, ChinaCollege of Information and Computer, Taiyuan University of Technology, Taiyuan, ChinaSchool of Life Science, Beijing Institute of Technology, Beijing, ChinaDepartment of Radiology, First Hospital of Shanxi Medical University, Taiyuan, ChinaCollege of Information and Computer, Taiyuan University of Technology, Taiyuan, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Health management, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, ChinaCollege of Information and Computer, Taiyuan University of Technology, Taiyuan, ChinaCollege of Information and Computer, Taiyuan University of Technology, Taiyuan, ChinaEmerging research indicates interruptions in the wiring organization of the brain network in Mild cognitive impairment (MCI) and Alzheimer's disease (AD). Due to the important role of rich-club organization in distinguishing abnormalities of AD patients and the close relationship between structural connectivity (SC) and functional connectivity (FC), our study examined whether changes in SC-FC coupling and the relationship with abnormal rich-club organizations during the development of diseases may contribute to the pathophysiology of AD. Structural diffusion-tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) were performed in 38 normal controls (NCs), 40 MCI patients and 19 AD patients. Measures of the rich-club structure and its role in global structural–functional coupling were administered. Our study found decreased levels of feeder and local connectivity in MCI and AD patients, which were the main contributing factors to the lower efficiency of the brain structural network. Another important finding was that we have more accurately characterized the changing pattern of functional brain dynamics. The enhanced coupling between SC and FC in MCI and AD patients might be due to disruptions in optimal structural organization. More interestingly, we also found increases in the SC-FC coupling for feeder and local connections in MCI and AD patients. SC-FC coupling also showed significant differences between MCI and AD patients, mainly between the abnormal feeder connections. The connection density and coupling strength were significantly correlated with clinical metrics in patients. The present findings enhanced our understanding of the neurophysiologic mechanisms associated with MCI and AD.https://www.frontiersin.org/article/10.3389/fneur.2020.00053/fullAlzheimer's diseasemild cognitive impairmentrich-club organizationSC-FC couplingbrain network |
| spellingShingle | Rui Cao Xin Wang Yuan Gao Ting Li Hui Zhang Waqar Hussain Yunyan Xie Jing Wang Bin Wang Jie Xiang Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease Frontiers in Neurology Alzheimer's disease mild cognitive impairment rich-club organization SC-FC coupling brain network |
| title | Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease |
| title_full | Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease |
| title_fullStr | Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease |
| title_full_unstemmed | Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease |
| title_short | Abnormal Anatomical Rich-Club Organization and Structural–Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease |
| title_sort | abnormal anatomical rich club organization and structural functional coupling in mild cognitive impairment and alzheimer s disease |
| topic | Alzheimer's disease mild cognitive impairment rich-club organization SC-FC coupling brain network |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00053/full |
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