Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review
Glioblastoma is the most common malignant tumor in the adult primary central nervous system. It has a strong proliferative ability, high recurrence rate, and high malignant degree. Despite standard radiotherapy combined with temozolomide chemotherapy, the prognosis was poor, with a 5-year survival o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Glioma |
| Subjects: | |
| Online Access: | http://www.jglioma.com/article.asp?issn=2589-6113;year=2023;volume=6;issue=1;spage=9;epage=14;aulast=Shao |
| _version_ | 1797824425856335872 |
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| author | Xiangxiang Shao Wei Ni Xiaobin Xu Yuanyuan Luo |
| author_facet | Xiangxiang Shao Wei Ni Xiaobin Xu Yuanyuan Luo |
| author_sort | Xiangxiang Shao |
| collection | DOAJ |
| description | Glioblastoma is the most common malignant tumor in the adult primary central nervous system. It has a strong proliferative ability, high recurrence rate, and high malignant degree. Despite standard radiotherapy combined with temozolomide chemotherapy, the prognosis was poor, with a 5-year survival of <10%. Therefore, more effective treatments need to be explored. Oncolytic viruses (OVs) have attracted the attention of researchers because of their unique targeting, safety, and antitumor effects. OV therapy has achieved remarkable efficacy in the treatment of many kinds of malignant tumors, and it has also made great progress in the treatment of glioblastoma. This article reviews the recent clinical research progress of OVs in the treatment of glioblastoma. |
| first_indexed | 2024-03-13T10:37:49Z |
| format | Article |
| id | doaj.art-2acbde74303a4a85913b1d222c77750c |
| institution | Directory Open Access Journal |
| issn | 2589-6113 2589-6121 |
| language | English |
| last_indexed | 2024-03-13T10:37:49Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Glioma |
| spelling | doaj.art-2acbde74303a4a85913b1d222c77750c2023-05-18T05:18:10ZengWolters Kluwer Medknow PublicationsGlioma2589-61132589-61212023-01-016191410.4103/glioma.glioma_3_23Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative reviewXiangxiang ShaoWei NiXiaobin XuYuanyuan LuoGlioblastoma is the most common malignant tumor in the adult primary central nervous system. It has a strong proliferative ability, high recurrence rate, and high malignant degree. Despite standard radiotherapy combined with temozolomide chemotherapy, the prognosis was poor, with a 5-year survival of <10%. Therefore, more effective treatments need to be explored. Oncolytic viruses (OVs) have attracted the attention of researchers because of their unique targeting, safety, and antitumor effects. OV therapy has achieved remarkable efficacy in the treatment of many kinds of malignant tumors, and it has also made great progress in the treatment of glioblastoma. This article reviews the recent clinical research progress of OVs in the treatment of glioblastoma.http://www.jglioma.com/article.asp?issn=2589-6113;year=2023;volume=6;issue=1;spage=9;epage=14;aulast=Shaoglioblastomamechanismoncolytic treatmentoncolytic virusprogress |
| spellingShingle | Xiangxiang Shao Wei Ni Xiaobin Xu Yuanyuan Luo Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review Glioma glioblastoma mechanism oncolytic treatment oncolytic virus progress |
| title | Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review |
| title_full | Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review |
| title_fullStr | Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review |
| title_full_unstemmed | Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review |
| title_short | Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review |
| title_sort | research progress in the treatment of glioblastoma by an oncolytic virus a narrative review |
| topic | glioblastoma mechanism oncolytic treatment oncolytic virus progress |
| url | http://www.jglioma.com/article.asp?issn=2589-6113;year=2023;volume=6;issue=1;spage=9;epage=14;aulast=Shao |
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