Circulating omentin concentration increases after weight loss
<p>Abstract</p> <p>Background</p> <p>Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating oment...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-04-01
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| Series: | Nutrition & Metabolism |
| Online Access: | http://www.nutritionandmetabolism.com/content/7/1/27 |
| _version_ | 1818553884844490752 |
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| author | Ricart Wifredo Gómez-Ambrosi Javier Ortega Francisco Catalán Victoria Moreno-Navarrete José Frühbeck Gema Fernández-Real José |
| author_facet | Ricart Wifredo Gómez-Ambrosi Javier Ortega Francisco Catalán Victoria Moreno-Navarrete José Frühbeck Gema Fernández-Real José |
| author_sort | Ricart Wifredo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations.</p> <p>Methods</p> <p>Circulating omentin-1 (ELISA) concentration in association with metabolic variables was measured in 35 obese subjects (18 men, 17 women) before and after hypocaloric weight loss.</p> <p>Results</p> <p>Baseline circulating omentin-1 concentrations correlated negatively with BMI (r = -0.58, p < 0.001), body weight (r = -0.35, p = 0.045), fat mass (r = -0.67, p < 0.001), circulating leptin (r = -0.7, p < 0.001) and fasting insulin (r = -0.37, p = 0.03). Circulating omentin-1 concentration increased significantly after weight loss (from 44.9 ± 9.02 to 53.41 ± 8.8 ng/ml, p < 0.001). This increase in circulating omentin after weight loss was associated with improved insulin sensitivity (negatively associated with HOMA value and fasting insulin, r = -0.42, p = 0.02 and r = -0.45, p = 0.01, respectively) and decreased BMI (r = -0.54, p = 0.001).</p> <p>Conclusion</p> <p>As previously described with adiponectin, circulating omentin-1 concentrations increase after weight loss-induced improvement of insulin sensitivity.</p> |
| first_indexed | 2024-12-12T09:31:39Z |
| format | Article |
| id | doaj.art-2ace4b029c25444fa31ff358e6544357 |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-12-12T09:31:39Z |
| publishDate | 2010-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-2ace4b029c25444fa31ff358e65443572022-12-22T00:28:50ZengBMCNutrition & Metabolism1743-70752010-04-01712710.1186/1743-7075-7-27Circulating omentin concentration increases after weight lossRicart WifredoGómez-Ambrosi JavierOrtega FranciscoCatalán VictoriaMoreno-Navarrete JoséFrühbeck GemaFernández-Real José<p>Abstract</p> <p>Background</p> <p>Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations.</p> <p>Methods</p> <p>Circulating omentin-1 (ELISA) concentration in association with metabolic variables was measured in 35 obese subjects (18 men, 17 women) before and after hypocaloric weight loss.</p> <p>Results</p> <p>Baseline circulating omentin-1 concentrations correlated negatively with BMI (r = -0.58, p < 0.001), body weight (r = -0.35, p = 0.045), fat mass (r = -0.67, p < 0.001), circulating leptin (r = -0.7, p < 0.001) and fasting insulin (r = -0.37, p = 0.03). Circulating omentin-1 concentration increased significantly after weight loss (from 44.9 ± 9.02 to 53.41 ± 8.8 ng/ml, p < 0.001). This increase in circulating omentin after weight loss was associated with improved insulin sensitivity (negatively associated with HOMA value and fasting insulin, r = -0.42, p = 0.02 and r = -0.45, p = 0.01, respectively) and decreased BMI (r = -0.54, p = 0.001).</p> <p>Conclusion</p> <p>As previously described with adiponectin, circulating omentin-1 concentrations increase after weight loss-induced improvement of insulin sensitivity.</p>http://www.nutritionandmetabolism.com/content/7/1/27 |
| spellingShingle | Ricart Wifredo Gómez-Ambrosi Javier Ortega Francisco Catalán Victoria Moreno-Navarrete José Frühbeck Gema Fernández-Real José Circulating omentin concentration increases after weight loss Nutrition & Metabolism |
| title | Circulating omentin concentration increases after weight loss |
| title_full | Circulating omentin concentration increases after weight loss |
| title_fullStr | Circulating omentin concentration increases after weight loss |
| title_full_unstemmed | Circulating omentin concentration increases after weight loss |
| title_short | Circulating omentin concentration increases after weight loss |
| title_sort | circulating omentin concentration increases after weight loss |
| url | http://www.nutritionandmetabolism.com/content/7/1/27 |
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