Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review
Abstract Strategies aiming to improve the longevity of resin–dentin adhesive interface developed so far have only been able to retard the problem. Different approaches are thus needed. The objective of this review was to determine whether the use of collagen-depletion strategies after acid-etching p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17371-0 |
| _version_ | 1811222409246670848 |
|---|---|
| author | António H. S. Delgado Madalena Belmar Da Costa Mário Cruz Polido Ana Mano Azul Salvatore Sauro |
| author_facet | António H. S. Delgado Madalena Belmar Da Costa Mário Cruz Polido Ana Mano Azul Salvatore Sauro |
| author_sort | António H. S. Delgado |
| collection | DOAJ |
| description | Abstract Strategies aiming to improve the longevity of resin–dentin adhesive interface developed so far have only been able to retard the problem. Different approaches are thus needed. The objective of this review was to determine whether the use of collagen-depletion strategies after acid-etching procedures may improve the bond strength of resin-based materials to dentin. A systematic review was planned following 2021 PRISMA statement guidelines, with a search strategy performed in five electronic databases: PubMed/Medline, Scopus, EMBASE, SciELO and IADR Abstract Archive (last search: 17/01/2022). Inclusion criteria encompassed studies which evaluated a collagen-depletion strategy in acid-etched human dentin and tensile/shear bond strength tests. Risk of bias assessment was carried out by two reviewers, working independently on an adapted five-domain risk of bias (RoB) checklist for laboratory studies. Results were synthesized qualitatively, as a meta-analysis was not possible due to limited number of studies and their RoB. A total of eight studies were eligible for inclusion in the systematic review after inclusion/exclusion criteria application. Out of these, two evaluated the effect of using NaOCl followed by an antioxidant, and the remaining six evaluated different enzymatic treatments (bromelain, chondroitinase ABC, papain, and trypsin). None of the studies reported a decrease of bond strength when a collagen-depletion strategy was used, in comparison to traditional hybrid layers (control). All enzymatic treatment studies which respected the inclusion criteria improved the bond strength to dentin. Some specific collagen-depletion strategies seem to play a favorable role in improving immediate bond strengths to dentin. Further research with sound methodology is required to consolidate these findings, since limitations in RoB and a low number of studies were found. The assessment of further proteolytic agents and long-term outcomes is also required. |
| first_indexed | 2024-04-12T08:15:23Z |
| format | Article |
| id | doaj.art-2acfc68101ec418cb090f8e3a11aca2f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T08:15:23Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2acfc68101ec418cb090f8e3a11aca2f2022-12-22T03:40:48ZengNature PortfolioScientific Reports2045-23222022-07-0112111310.1038/s41598-022-17371-0Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic reviewAntónio H. S. Delgado0Madalena Belmar Da Costa1Mário Cruz Polido2Ana Mano Azul3Salvatore Sauro4Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM)Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM)Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM)Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM)Dental Biomaterials and Minimally Invasive Dentistry, Department of Dentistry, Cardenal Herrera-CEU University, CEU UniversitiesAbstract Strategies aiming to improve the longevity of resin–dentin adhesive interface developed so far have only been able to retard the problem. Different approaches are thus needed. The objective of this review was to determine whether the use of collagen-depletion strategies after acid-etching procedures may improve the bond strength of resin-based materials to dentin. A systematic review was planned following 2021 PRISMA statement guidelines, with a search strategy performed in five electronic databases: PubMed/Medline, Scopus, EMBASE, SciELO and IADR Abstract Archive (last search: 17/01/2022). Inclusion criteria encompassed studies which evaluated a collagen-depletion strategy in acid-etched human dentin and tensile/shear bond strength tests. Risk of bias assessment was carried out by two reviewers, working independently on an adapted five-domain risk of bias (RoB) checklist for laboratory studies. Results were synthesized qualitatively, as a meta-analysis was not possible due to limited number of studies and their RoB. A total of eight studies were eligible for inclusion in the systematic review after inclusion/exclusion criteria application. Out of these, two evaluated the effect of using NaOCl followed by an antioxidant, and the remaining six evaluated different enzymatic treatments (bromelain, chondroitinase ABC, papain, and trypsin). None of the studies reported a decrease of bond strength when a collagen-depletion strategy was used, in comparison to traditional hybrid layers (control). All enzymatic treatment studies which respected the inclusion criteria improved the bond strength to dentin. Some specific collagen-depletion strategies seem to play a favorable role in improving immediate bond strengths to dentin. Further research with sound methodology is required to consolidate these findings, since limitations in RoB and a low number of studies were found. The assessment of further proteolytic agents and long-term outcomes is also required.https://doi.org/10.1038/s41598-022-17371-0 |
| spellingShingle | António H. S. Delgado Madalena Belmar Da Costa Mário Cruz Polido Ana Mano Azul Salvatore Sauro Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review Scientific Reports |
| title | Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review |
| title_full | Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review |
| title_fullStr | Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review |
| title_full_unstemmed | Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review |
| title_short | Collagen-depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength: a systematic review |
| title_sort | collagen depletion strategies in dentin as alternatives to the hybrid layer concept and their effect on bond strength a systematic review |
| url | https://doi.org/10.1038/s41598-022-17371-0 |
| work_keys_str_mv | AT antoniohsdelgado collagendepletionstrategiesindentinasalternativestothehybridlayerconceptandtheireffectonbondstrengthasystematicreview AT madalenabelmardacosta collagendepletionstrategiesindentinasalternativestothehybridlayerconceptandtheireffectonbondstrengthasystematicreview AT mariocruzpolido collagendepletionstrategiesindentinasalternativestothehybridlayerconceptandtheireffectonbondstrengthasystematicreview AT anamanoazul collagendepletionstrategiesindentinasalternativestothehybridlayerconceptandtheireffectonbondstrengthasystematicreview AT salvatoresauro collagendepletionstrategiesindentinasalternativestothehybridlayerconceptandtheireffectonbondstrengthasystematicreview |