Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase

Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase

Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these...

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Bibliographic Details
Main Authors: Michael D. Threadgill, Claire L.M. Goodyer, Ghadeer A.R.Y. Suaifan
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Molecules
Subjects:
nitric oxide synthase
iNOS
stimulation
thienylmethylthioureas
Online Access:http://www.mdpi.com/1420-3049/15/5/3121/

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