FGF21 negatively affects long-term female fertility in mice

FGF21 negatively affects long-term female fertility in mice

Objective: Obesity and associated liver disease are a growing public health concern. Pharmacological agents to treat non-alcoholic fatty liver disease are limited. FGF21, a hormone secreted by the liver and potent metabolic modulator, is a promising therapeutic target for this indication with severa...

Full description

Bibliographic Details
Main Authors:	Beat Moeckli, Thuy-Vy Pham, Florence Slits, Samuel Latrille, Andrea Peloso, Vaihere Delaune, Graziano Oldani, Stéphanie Lacotte, Christian Toso
Format:	Article
Language:	English
Published:	Elsevier 2022-11-01
Series:	Heliyon
Subjects:	FGF21 Fertility Non-alcoholic fatty liver disease High-fat diet
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844022027785

Similar Items

Localization of FGF21 Protein and Lipid Metabolism-Related Genes in Camels
by: Yuan Gao, et al.
Published: (2023-02-01)

The Suitability of FGF21 and FGF23 as New Biomarkers in Endometrial Cancer Patients
by: Aneta Cymbaluk-Płoska, et al.
Published: (2020-06-01)

Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue
by: Marlou Klein Hazebroek, et al.
Published: (2022-08-01)

Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho
by: Alexandra S. Aaldijk, et al.
Published: (2023-05-01)

The role of FGF21 and its analogs on liver associated diseases
by: Kimia Falamarzi, et al.
Published: (2022-11-01)

Epigenetic regulation of GABA catabolism in iPSC-derived neurons: The molecular links between FGF21 and histone methylation
by: Ming-Fen Ho, et al.
Published: (2023-11-01)

Impact of Maternal Obesity on Liver Disease in the Offspring: A Comprehensive Transcriptomic Analysis and Confirmation of Results in a Murine Model
by: Beat Moeckli, et al.
Published: (2022-01-01)

Decreased FGF19 and FGF21: possible underlying common pathogenic mechanism of metabolic and cognitive dysregulation in depression
by: Mimi Tang, et al.
Published: (2023-05-01)

Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21–AMPK pathway in mice fed a high fat diet
by: Yuanyuan Zhang, et al.
Published: (2022-04-01)

Short‐term semaglutide treatment improves FGF21 responsiveness in primary hepatocytes isolated from high fat diet challenged mice
by: Jia Nuo Feng, et al.
Published: (2023-03-01)

FGF21: A Sharp Weapon in the Process of Exercise to Improve NAFLD
by: Zhiyuan Wang, et al.
Published: (2023-12-01)

Physical Exercise-Induced FGF-21 to Fight Obesity: An Update Review
by: Bruno Vecchiatto, et al.
Published: (2022-11-01)

Analysis of Functional Promoter of Camel FGF21 Gene and Identification of Small Compounds Targeting FGF21 Protein
by: Fang Yong, et al.
Published: (2023-07-01)

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response
by: Iroz, Alison, et al.
Published: (2017)

Genome-wide association study for circulating FGF21 in patients with alcohol use disorder: Molecular links between the SNHG16 locus and catecholamine metabolism
by: Ming-Fen Ho, et al.
Published: (2022-09-01)

Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation
by: Fengyuan Li, et al.
Published: (2021-11-01)

Liver Brain Interactions: Focus on FGF21 a Systematic Review
by: Eva Prida, et al.
Published: (2022-11-01)

FGF21 Levels in Pheochromocytoma/Functional Paraganglioma
by: Judita Klímová, et al.
Published: (2019-04-01)

The Mitochondrial Biomarkers FGF-21 and GDF-15 in Patients with Episodic and Chronic Migraine
by: Philipp Burow, et al.
Published: (2021-09-01)

Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases
by: Irem Darka Aslan, et al.
Published: (2023-06-01)

Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity
by: Kristin E. Claflin, et al.
Published: (2022-10-01)

RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy
by: Yeli Zhao, et al.
Published: (2022-10-01)

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice
by: Zhongjie Fu, et al.
Published: (2017-02-01)

The Diagnostic Role of FGF 21 in Endometrial Cancer and Other Pathologies of the Uterine Corpus
by: Anna Jagodzińska, et al.
Published: (2023-01-01)

The Effect of a Life-Style Intervention Program of Diet and Exercise on Irisin and FGF-21 Concentrations in Children and Adolescents with Overweight and Obesity
by: Sofia I. Karampatsou, et al.
Published: (2021-04-01)

CRISPRa system activates myokines FGF21 and FNDC5: Promoting fat browning and improving diet‐induced obesity in mice
by: Rui Jiang, et al.
Published: (2023-08-01)

Alteration of cognitive function in overweight and obese adolescents and its relationship with serum FGF21 levels
by: HAN Rui, et al.
Published: (2024-01-01)

FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability
by: Jiahui He, et al.
Published: (2023-03-01)

Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans
by: Thomas P.J. Solomon, et al.
Published: (2022-01-01)

Editorial: FGF21 as a therapeutic target for obesity and insulin resistance: from rodent models to humans
by: A. L. De Sousa-Coelho, et al.
Published: (2023-08-01)

FGF21 gene therapy as treatment for obesity and insulin resistance
by: Veronica Jimenez, et al.
Published: (2018-08-01)

Maternal obesity increases the risk of hepatocellular carcinoma through the transmission of an altered gut microbiome
by: Beat Moeckli, et al.
Published: (2024-05-01)

The effect of aerobic and resistance exercise on sugar indicators and FGF21 in cardiac tissue of diabetic rat
by: Amir Mounesan, et al.
Published: (2023-12-01)

Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production
by: Jiayu Xu, et al.
Published: (2023-10-01)

Adhesive, injectable, and ROS-responsive hybrid polyvinyl alcohol (PVA) hydrogel co-delivers metformin and fibroblast growth factor 21 (FGF21) for enhanced diabetic wound repair
by: Hong Zhu, et al.
Published: (2022-08-01)

Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD
by: Takeshi eInagaki
Published: (2015-09-01)

Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP–Epac–CREB Signaling Pathway
by: Yan-Yan Zhao, et al.
Published: (2022-05-01)

Regeneration of Non-Alcoholic Fatty Liver Cells Using Chimeric FGF21/HGFR: A Novel Therapeutic Approach
by: Sung-Jun Kim, et al.
Published: (2024-03-01)

Effect of High-Intensity Interval Training and Portulaca Oleracea Extract Supplementation on FGF-21 Level and Insulin Resistance in Rats with Non-Alcoholic Fatty Liver Disease
by: Mohammad Ranaei, et al.
Published: (2023-06-01)

Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice
by: Satish Patel, et al.
Published: (2022-11-01)