Direct neurotransmitter activation of voltage-gated potassium channels
M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine. Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04266-w |
| _version_ | 1818855912835645440 |
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| author | Rían W. Manville Maria Papanikolaou Geoffrey W. Abbott |
| author_facet | Rían W. Manville Maria Papanikolaou Geoffrey W. Abbott |
| author_sort | Rían W. Manville |
| collection | DOAJ |
| description | M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine. Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity. |
| first_indexed | 2024-12-19T08:16:09Z |
| format | Article |
| id | doaj.art-2ad40d9af26245ef824e15348a069d8d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:16:09Z |
| publishDate | 2018-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2ad40d9af26245ef824e15348a069d8d2022-12-21T20:29:30ZengNature PortfolioNature Communications2041-17232018-05-019111310.1038/s41467-018-04266-wDirect neurotransmitter activation of voltage-gated potassium channelsRían W. Manville0Maria Papanikolaou1Geoffrey W. Abbott2Department of Physiology and Biophysics, Bioelectricity Laboratory, Medical Sciences D, ZOT 4560, School of Medicine, University of CaliforniaDepartment of Physiology and Biophysics, Bioelectricity Laboratory, Medical Sciences D, ZOT 4560, School of Medicine, University of CaliforniaDepartment of Physiology and Biophysics, Bioelectricity Laboratory, Medical Sciences D, ZOT 4560, School of Medicine, University of CaliforniaM-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine. Here the authors show that GABA directly activates KCNQ3, at the residue required for its anticonvulsant activity.https://doi.org/10.1038/s41467-018-04266-w |
| spellingShingle | Rían W. Manville Maria Papanikolaou Geoffrey W. Abbott Direct neurotransmitter activation of voltage-gated potassium channels Nature Communications |
| title | Direct neurotransmitter activation of voltage-gated potassium channels |
| title_full | Direct neurotransmitter activation of voltage-gated potassium channels |
| title_fullStr | Direct neurotransmitter activation of voltage-gated potassium channels |
| title_full_unstemmed | Direct neurotransmitter activation of voltage-gated potassium channels |
| title_short | Direct neurotransmitter activation of voltage-gated potassium channels |
| title_sort | direct neurotransmitter activation of voltage gated potassium channels |
| url | https://doi.org/10.1038/s41467-018-04266-w |
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