Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis
Objective: To investigate the association between serum concentration of insulin-like growth factor (IGF) and the risk of pancreatic cancer (PaC). Methods: We identified eligible studies in Medline and EMBASE databases (no reference trials from 2014 to 2016) in addition to the reference lists of ori...
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MDPI AG
2017-04-01
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| Series: | Nutrients |
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| Online Access: | http://www.mdpi.com/2072-6643/9/4/394 |
| _version_ | 1811278283060281344 |
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| author | Yuanfeng Gong Bingyi Zhang Yadi Liao Yunqiang Tang Cong Mai Tiejun Chen Hui Tang |
| author_facet | Yuanfeng Gong Bingyi Zhang Yadi Liao Yunqiang Tang Cong Mai Tiejun Chen Hui Tang |
| author_sort | Yuanfeng Gong |
| collection | DOAJ |
| description | Objective: To investigate the association between serum concentration of insulin-like growth factor (IGF) and the risk of pancreatic cancer (PaC). Methods: We identified eligible studies in Medline and EMBASE databases (no reference trials from 2014 to 2016) in addition to the reference lists of original studies and review articles on this topic. A summary of relative risks with 95% confidence intervals (CI) was calculated using a random-effects model. The heterogeneity between studies was assessed using Cochran Q and I2 statistics. Results: Ten studies (seven nested case-control studies and three retrospective case-control studies) were selected as they met our inclusion criteria in this meta-analysis. All these studies were published between 1997 and 2013. The current data suggested that serum concentrations of IGF-I, IGF-II and insulin-like growth factor binding protein-3 (IGFBP-3)in addition to the IGF-I/IGFBP-3 ratio were not associated with an increased risk of PaC (Summary relative risks (SRRs) = 0.92, 95% CI: 0.67–1.16 for IGF-I; SRRs = 0.84, 95% CI: 0.54–1.15 for IGF-II; SRRs = 0.93, 95% CI: 0.69–1.17 for IGFBP-3; SRRs = 0.97, 95% CI: 0.71–1.23 for IGF-I/IGFBP-3 ratio). There was no publication bias in the present meta-analysis. Conclusion: Serum concentrations of IGF-I, IGF-II, IGFBP-1 and IGFBP-3 as well as the IGF-I/IGFBP-3 ratio were not associated with increased risk of PaC. |
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| language | English |
| last_indexed | 2024-04-13T00:33:03Z |
| publishDate | 2017-04-01 |
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| series | Nutrients |
| spelling | doaj.art-2ad6c683b9f04acfba0e4c73551a82552022-12-22T03:10:25ZengMDPI AGNutrients2072-66432017-04-019439410.3390/nu9040394nu9040394Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-AnalysisYuanfeng Gong0Bingyi Zhang1Yadi Liao2Yunqiang Tang3Cong Mai4Tiejun Chen5Hui Tang6Department of Hepatobiliary Surgery, The Affiliated Cancer Hospital& Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Ultrasound, the First People’s Hospital of Yichang, China Three Gorges University, Yichang 443000, ChinaDepartment of Hepatobiliary Surgery, The Affiliated Cancer Hospital& Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Hepatobiliary Surgery, The Affiliated Cancer Hospital& Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Hepatobiliary Surgery, The Affiliated Cancer Hospital& Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Hepatobiliary Surgery, The Affiliated Cancer Hospital& Institute of Guangzhou Medical University, Guangzhou 510095, ChinaDepartment of Hepatobiliary Surgery, The Affiliated Cancer Hospital& Institute of Guangzhou Medical University, Guangzhou 510095, ChinaObjective: To investigate the association between serum concentration of insulin-like growth factor (IGF) and the risk of pancreatic cancer (PaC). Methods: We identified eligible studies in Medline and EMBASE databases (no reference trials from 2014 to 2016) in addition to the reference lists of original studies and review articles on this topic. A summary of relative risks with 95% confidence intervals (CI) was calculated using a random-effects model. The heterogeneity between studies was assessed using Cochran Q and I2 statistics. Results: Ten studies (seven nested case-control studies and three retrospective case-control studies) were selected as they met our inclusion criteria in this meta-analysis. All these studies were published between 1997 and 2013. The current data suggested that serum concentrations of IGF-I, IGF-II and insulin-like growth factor binding protein-3 (IGFBP-3)in addition to the IGF-I/IGFBP-3 ratio were not associated with an increased risk of PaC (Summary relative risks (SRRs) = 0.92, 95% CI: 0.67–1.16 for IGF-I; SRRs = 0.84, 95% CI: 0.54–1.15 for IGF-II; SRRs = 0.93, 95% CI: 0.69–1.17 for IGFBP-3; SRRs = 0.97, 95% CI: 0.71–1.23 for IGF-I/IGFBP-3 ratio). There was no publication bias in the present meta-analysis. Conclusion: Serum concentrations of IGF-I, IGF-II, IGFBP-1 and IGFBP-3 as well as the IGF-I/IGFBP-3 ratio were not associated with increased risk of PaC.http://www.mdpi.com/2072-6643/9/4/394insulin-like growth factorinsulin-like growth factor binding proteinpancreatic cancermorbiditymeta-analysis |
| spellingShingle | Yuanfeng Gong Bingyi Zhang Yadi Liao Yunqiang Tang Cong Mai Tiejun Chen Hui Tang Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis Nutrients insulin-like growth factor insulin-like growth factor binding protein pancreatic cancer morbidity meta-analysis |
| title | Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis |
| title_full | Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis |
| title_fullStr | Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis |
| title_short | Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis |
| title_sort | serum insulin like growth factor axis and the risk of pancreatic cancer systematic review and meta analysis |
| topic | insulin-like growth factor insulin-like growth factor binding protein pancreatic cancer morbidity meta-analysis |
| url | http://www.mdpi.com/2072-6643/9/4/394 |
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