Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study
ABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222&lng=en&tlng=en |
| _version_ | 1818197001254207488 |
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| author | Vitor Breseghello Cavenaghi Fernanda Martinho Dobrianskyj Guilherme Sciascia do Olival Rafael Paternò Castello Dias Carneiro Charles Peter Tilbery |
| author_facet | Vitor Breseghello Cavenaghi Fernanda Martinho Dobrianskyj Guilherme Sciascia do Olival Rafael Paternò Castello Dias Carneiro Charles Peter Tilbery |
| author_sort | Vitor Breseghello Cavenaghi |
| collection | DOAJ |
| description | ABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of multiple sclerosis in a Brazilian medical center. DESIGN AND SETTING: Descriptive study, conducted in a Brazilian reference center for multiple sclerosis treatment. METHODS: Data on 299 patients with confirmed diagnoses of MS were included in the study. Their medical files were evaluated and the data were analyzed. RESULTS: The most common symptom involved the cranial nerves (50.83%) and unifocal manifestation was presented by the majority of this population (73.91%). The mean time between the first symptom and the diagnosis was 2.84 years. Unifocal symptoms correlated with longer time taken to establish the diagnosis, with an average of 3.20 years, while for multifocal symptoms the average time taken for the diagnosis was 1.85 years. Unifocal onset was related to greater diagnostic difficulty. CONCLUSIONS: MS is a heterogeneous disease and its initial clinical manifestation is very variable. |
| first_indexed | 2024-12-12T01:43:02Z |
| format | Article |
| id | doaj.art-2ad756e1fc34493285936196f9b29270 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-12T01:43:02Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-2ad756e1fc34493285936196f9b292702022-12-22T00:42:39ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460135322222510.1590/1516-3180.2016.0200270117S1516-31802017000300222Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional studyVitor Breseghello CavenaghiFernanda Martinho DobrianskyjGuilherme Sciascia do OlivalRafael Paternò Castello Dias CarneiroCharles Peter TilberyABSTRACT CONTEXT AND OBJECTIVE: Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative central nervous system (CNS) disease with well-established diagnostic criteria. Treatment can modify the course of the disease. The objective of this study was to describe the initial symptoms of multiple sclerosis in a Brazilian medical center. DESIGN AND SETTING: Descriptive study, conducted in a Brazilian reference center for multiple sclerosis treatment. METHODS: Data on 299 patients with confirmed diagnoses of MS were included in the study. Their medical files were evaluated and the data were analyzed. RESULTS: The most common symptom involved the cranial nerves (50.83%) and unifocal manifestation was presented by the majority of this population (73.91%). The mean time between the first symptom and the diagnosis was 2.84 years. Unifocal symptoms correlated with longer time taken to establish the diagnosis, with an average of 3.20 years, while for multifocal symptoms the average time taken for the diagnosis was 1.85 years. Unifocal onset was related to greater diagnostic difficulty. CONCLUSIONS: MS is a heterogeneous disease and its initial clinical manifestation is very variable.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222&lng=en&tlng=enMultiple sclerosisAcademic medical centersSymptom assessmentIllness behaviorCranial nerves |
| spellingShingle | Vitor Breseghello Cavenaghi Fernanda Martinho Dobrianskyj Guilherme Sciascia do Olival Rafael Paternò Castello Dias Carneiro Charles Peter Tilbery Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study São Paulo Medical Journal Multiple sclerosis Academic medical centers Symptom assessment Illness behavior Cranial nerves |
| title | Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
| title_full | Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
| title_fullStr | Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
| title_full_unstemmed | Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
| title_short | Characterization of the first symptoms of multiple sclerosis in a Brazilian center: cross-sectional study |
| title_sort | characterization of the first symptoms of multiple sclerosis in a brazilian center cross sectional study |
| topic | Multiple sclerosis Academic medical centers Symptom assessment Illness behavior Cranial nerves |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017000300222&lng=en&tlng=en |
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