Primary localized ileal amyloidosis with chronic ileitis: a case report with review of literature
Abstract Amyloidosis is a rare condition where fibrillar proteins and abnormal, soluble peptides accumulate throughout the body’s organs. Gastrointestinal symptoms secondary to amyloid deposition vary widely and may be confused with other common small intestine diseases, making the diagnosis challen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-07-01
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| Series: | The Egyptian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43162-023-00237-w |
| _version_ | 1827894874080280576 |
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| author | Mahmod Ghoname Hazem Abosheaishaa Mostafa Shehata Mohammed Abdelwahed Moataz Yousry Soliman |
| author_facet | Mahmod Ghoname Hazem Abosheaishaa Mostafa Shehata Mohammed Abdelwahed Moataz Yousry Soliman |
| author_sort | Mahmod Ghoname |
| collection | DOAJ |
| description | Abstract Amyloidosis is a rare condition where fibrillar proteins and abnormal, soluble peptides accumulate throughout the body’s organs. Gastrointestinal symptoms secondary to amyloid deposition vary widely and may be confused with other common small intestine diseases, making the diagnosis challenging. Our case is a 63-year-old male with a past medical history of smoking who showed up in the ED with 5 months of diffuse abdominal pain referred to the back. Pelvis-abdominal ultrasound showed bilateral acute pyelonephritis. A colonoscopy revealed large multiple ileal ulcers about 10 cm from the ileocecal valve with a wide base. Pathology biopsies revealed ileal amyloidosis and chronic ileitis with superficial erosions. The patient has been diagnosed with primary localized ileal AL amyloidosis. The patient has finally been referred for surgical resection. We want to raise awareness of ileal amyloidosis and emphasize the importance of considering uncommon etiologies of small intestine pathology in patients presenting with chronic diarrhea, malabsorption, abdominal pain, and weight loss. Finally, patients with small intestine amyloid disease progressing rapidly and failing to respond to non-surgical treatment should be considered for surgical resection. |
| first_indexed | 2024-03-12T22:12:43Z |
| format | Article |
| id | doaj.art-2ada7f86cd4b444586b6fc859d32a554 |
| institution | Directory Open Access Journal |
| issn | 2090-9098 |
| language | English |
| last_indexed | 2024-03-12T22:12:43Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj.art-2ada7f86cd4b444586b6fc859d32a5542023-07-23T11:27:00ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982023-07-013511510.1186/s43162-023-00237-wPrimary localized ileal amyloidosis with chronic ileitis: a case report with review of literatureMahmod Ghoname0Hazem Abosheaishaa1Mostafa Shehata2Mohammed Abdelwahed3Moataz Yousry Soliman4Department of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine, Al-Azhar UniversityDepartment of Internal Medicine, Icahn School of Medicine at Mount Sinai |NYC Health + Hospitals QueensDepartment of Hepatology Gastroenterology and Infectious, Ahmed Maher Teaching Hospital, Egyptian Ministry of Health and PopulationDepartment of Pathology, Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellDepartment of Hepatology, Gastroenterology and Infectious Diseases Faculty of Medicine, Al-Azhar UniversityAbstract Amyloidosis is a rare condition where fibrillar proteins and abnormal, soluble peptides accumulate throughout the body’s organs. Gastrointestinal symptoms secondary to amyloid deposition vary widely and may be confused with other common small intestine diseases, making the diagnosis challenging. Our case is a 63-year-old male with a past medical history of smoking who showed up in the ED with 5 months of diffuse abdominal pain referred to the back. Pelvis-abdominal ultrasound showed bilateral acute pyelonephritis. A colonoscopy revealed large multiple ileal ulcers about 10 cm from the ileocecal valve with a wide base. Pathology biopsies revealed ileal amyloidosis and chronic ileitis with superficial erosions. The patient has been diagnosed with primary localized ileal AL amyloidosis. The patient has finally been referred for surgical resection. We want to raise awareness of ileal amyloidosis and emphasize the importance of considering uncommon etiologies of small intestine pathology in patients presenting with chronic diarrhea, malabsorption, abdominal pain, and weight loss. Finally, patients with small intestine amyloid disease progressing rapidly and failing to respond to non-surgical treatment should be considered for surgical resection.https://doi.org/10.1186/s43162-023-00237-wSmall intestineAmyloidosisCrohn’s diseaseChronic diarrheaAbdominal pain |
| spellingShingle | Mahmod Ghoname Hazem Abosheaishaa Mostafa Shehata Mohammed Abdelwahed Moataz Yousry Soliman Primary localized ileal amyloidosis with chronic ileitis: a case report with review of literature The Egyptian Journal of Internal Medicine Small intestine Amyloidosis Crohn’s disease Chronic diarrhea Abdominal pain |
| title | Primary localized ileal amyloidosis with chronic ileitis: a case report with review of literature |
| title_full | Primary localized ileal amyloidosis with chronic ileitis: a case report with review of literature |
| title_fullStr | Primary localized ileal amyloidosis with chronic ileitis: a case report with review of literature |
| title_full_unstemmed | Primary localized ileal amyloidosis with chronic ileitis: a case report with review of literature |
| title_short | Primary localized ileal amyloidosis with chronic ileitis: a case report with review of literature |
| title_sort | primary localized ileal amyloidosis with chronic ileitis a case report with review of literature |
| topic | Small intestine Amyloidosis Crohn’s disease Chronic diarrhea Abdominal pain |
| url | https://doi.org/10.1186/s43162-023-00237-w |
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