Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases
For over three centuries, hydrogen sulfide (H2S) has been known as a toxic and deadly gas at high concentrations, with a distinctive smell of rotten eggs. However, studies over the past two decades have shown that H2S has risen above its historically notorious label and has now received significant...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223011940 |
| _version_ | 1797686840866635776 |
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| author | George J. Dugbartey |
| author_facet | George J. Dugbartey |
| author_sort | George J. Dugbartey |
| collection | DOAJ |
| description | For over three centuries, hydrogen sulfide (H2S) has been known as a toxic and deadly gas at high concentrations, with a distinctive smell of rotten eggs. However, studies over the past two decades have shown that H2S has risen above its historically notorious label and has now received significant scientific attention as an endogenously produced gaseous signaling molecule that participates in cellular homeostasis and influences a myriad of physiological and pathological processes at low concentrations. Its endogenous production is enzymatically regulated, and when dysregulated, contributes to pathogenesis of renal diseases. In addition, exogenous H2S administration has been reported to exhibit important therapeutic characteristics that target multiple molecular pathways in common renal pathologies in which reduced levels of renal and plasma H2S were observed. This review highlights functional anatomy of the kidney and renal production of H2S. The review also discusses current understanding of H2S in renal physiology and seeks to lay the foundation as a new targeted therapeutic agent for renal pathologies such as hypertensive nephropathy, diabetic kidney disease and water balance disorders. |
| first_indexed | 2024-03-12T01:10:30Z |
| format | Article |
| id | doaj.art-2add394f263d45d2b9d9f800b3ee57a1 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:10:30Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-2add394f263d45d2b9d9f800b3ee57a12023-09-14T04:52:54ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115396Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseasesGeorge J. Dugbartey0Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, Ghana; Accra College of Medicine, Magnolia St, JVX5+FX9, East Legon, Accra, Ghana; Corresponding author at: Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.For over three centuries, hydrogen sulfide (H2S) has been known as a toxic and deadly gas at high concentrations, with a distinctive smell of rotten eggs. However, studies over the past two decades have shown that H2S has risen above its historically notorious label and has now received significant scientific attention as an endogenously produced gaseous signaling molecule that participates in cellular homeostasis and influences a myriad of physiological and pathological processes at low concentrations. Its endogenous production is enzymatically regulated, and when dysregulated, contributes to pathogenesis of renal diseases. In addition, exogenous H2S administration has been reported to exhibit important therapeutic characteristics that target multiple molecular pathways in common renal pathologies in which reduced levels of renal and plasma H2S were observed. This review highlights functional anatomy of the kidney and renal production of H2S. The review also discusses current understanding of H2S in renal physiology and seeks to lay the foundation as a new targeted therapeutic agent for renal pathologies such as hypertensive nephropathy, diabetic kidney disease and water balance disorders.http://www.sciencedirect.com/science/article/pii/S0753332223011940Hydrogen sulfide (H2S)Sodium-potassium-ATPase (Na+/K+-ATPase)Sodium-potassium-chloride (Na+-K+-2Cl-) cotransporterRenal blood flow (RBF)Glomerular filtration rate (GFR)H2S-producing enzymes |
| spellingShingle | George J. Dugbartey Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases Biomedicine & Pharmacotherapy Hydrogen sulfide (H2S) Sodium-potassium-ATPase (Na+/K+-ATPase) Sodium-potassium-chloride (Na+-K+-2Cl-) cotransporter Renal blood flow (RBF) Glomerular filtration rate (GFR) H2S-producing enzymes |
| title | Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases |
| title_full | Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases |
| title_fullStr | Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases |
| title_full_unstemmed | Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases |
| title_short | Physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases |
| title_sort | physiological role of hydrogen sulfide in the kidney and its therapeutic implications for kidney diseases |
| topic | Hydrogen sulfide (H2S) Sodium-potassium-ATPase (Na+/K+-ATPase) Sodium-potassium-chloride (Na+-K+-2Cl-) cotransporter Renal blood flow (RBF) Glomerular filtration rate (GFR) H2S-producing enzymes |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223011940 |
| work_keys_str_mv | AT georgejdugbartey physiologicalroleofhydrogensulfideinthekidneyanditstherapeuticimplicationsforkidneydiseases |