Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation

Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation

Introduction: Hyperphosphorylated Tau protein (PPTau) is the hallmark of tauopathic neurodegeneration. During “synthetic torpor” (ST), a transient hypothermic state which can be induced in rats by the local pharmacological inhibition of the Raphe Pallidus, a reversible brain Tau hyperphosphorylation...

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Bibliographic Details
Main Authors: Fabio Squarcio, Timna Hitrec, Emiliana Piscitiello, Matteo Cerri, Catia Giovannini, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Physiology
Subjects:
deep hypothermia
microtubules
melatonin
glycogen synthase kinase 3β
hippocampus
parietal cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1129278/full

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