MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTS
In this review, we discuss the advantages and disadvantages of the existing bone defect animal models and tissue engineering techniques applied in studying novel bone defect regenerative approaches. The paper suggests the requirements for an optimal animal model, as well as analyzes in vivo bone inj...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1
2021-03-01
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| Series: | Инновационная медицина Кубани |
| Subjects: | |
| Online Access: | https://www.innovmedkub.ru/jour/article/view/374 |
| _version_ | 1826575563746181120 |
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| author | A. Sh. Ananeva L. M. Baraeva I. M. Bykov Yu. V. Verevkina A. N. Kurzanov |
| author_facet | A. Sh. Ananeva L. M. Baraeva I. M. Bykov Yu. V. Verevkina A. N. Kurzanov |
| author_sort | A. Sh. Ananeva |
| collection | DOAJ |
| description | In this review, we discuss the advantages and disadvantages of the existing bone defect animal models and tissue engineering techniques applied in studying novel bone defect regenerative approaches. The paper suggests the requirements for an optimal animal model, as well as analyzes in vivo bone injury models widely used in testing. The authors briefly review the methods of experimentally produced lesions of long bones, calvarial bones, mandibular bones in different animals. This review also describes the standardization techniques allowing one to evaluate the process of osteogenesis and bone-implant interactions. That will help researchers thoroughly plan and conduct experiments according to the bioethical principles. |
| first_indexed | 2024-03-07T15:35:30Z |
| format | Article |
| id | doaj.art-2ae022f8db744e16a4deb7562d3d0ff4 |
| institution | Directory Open Access Journal |
| issn | 2541-9897 |
| language | Russian |
| last_indexed | 2025-03-14T13:16:42Z |
| publishDate | 2021-03-01 |
| publisher | Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1 |
| record_format | Article |
| series | Инновационная медицина Кубани |
| spelling | doaj.art-2ae022f8db744e16a4deb7562d3d0ff42025-02-28T14:50:41ZrusScientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1Инновационная медицина Кубани2541-98972021-03-0101475510.35401/2500-0268-2021-21-1-47-55271MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTSA. Sh. Ananeva0L. M. Baraeva1I. M. Bykov2Yu. V. Verevkina3A. N. Kurzanov4Kuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityIn this review, we discuss the advantages and disadvantages of the existing bone defect animal models and tissue engineering techniques applied in studying novel bone defect regenerative approaches. The paper suggests the requirements for an optimal animal model, as well as analyzes in vivo bone injury models widely used in testing. The authors briefly review the methods of experimentally produced lesions of long bones, calvarial bones, mandibular bones in different animals. This review also describes the standardization techniques allowing one to evaluate the process of osteogenesis and bone-implant interactions. That will help researchers thoroughly plan and conduct experiments according to the bioethical principles.https://www.innovmedkub.ru/jour/article/view/374regenerative medicinebone regenerationbone defecttissue engineering constructpreclinical researchclinical efficacy |
| spellingShingle | A. Sh. Ananeva L. M. Baraeva I. M. Bykov Yu. V. Verevkina A. N. Kurzanov MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTS Инновационная медицина Кубани regenerative medicine bone regeneration bone defect tissue engineering construct preclinical research clinical efficacy |
| title | MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTS |
| title_full | MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTS |
| title_fullStr | MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTS |
| title_full_unstemmed | MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTS |
| title_short | MODELING OF BONE INJURIES IN ANIMAL EXPERIMENTS |
| title_sort | modeling of bone injuries in animal experiments |
| topic | regenerative medicine bone regeneration bone defect tissue engineering construct preclinical research clinical efficacy |
| url | https://www.innovmedkub.ru/jour/article/view/374 |
| work_keys_str_mv | AT ashananeva modelingofboneinjuriesinanimalexperiments AT lmbaraeva modelingofboneinjuriesinanimalexperiments AT imbykov modelingofboneinjuriesinanimalexperiments AT yuvverevkina modelingofboneinjuriesinanimalexperiments AT ankurzanov modelingofboneinjuriesinanimalexperiments |