COVID-19 in patients with paracoccidioidomycosis.
<h4>Introduction</h4>In 2020, we reported the first patient with concomitant COVID-19 and paracoccidioidomycosis (PCM). Since then, no other cases have been recorded in the literature. We aim to update information on the occurrence of COVID-19 in patients with PCM followed at a reference...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-05-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0011322 |
| _version_ | 1827940477580607488 |
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| author | Priscila Marques de Macedo Lorena Macedo Pestana Benko Eduardo Mastrangelo Marinho Falcão Joshua D Nosanchuk Rodrigo Almeida-Paes Antonio Carlos Francesconi do Valle |
| author_facet | Priscila Marques de Macedo Lorena Macedo Pestana Benko Eduardo Mastrangelo Marinho Falcão Joshua D Nosanchuk Rodrigo Almeida-Paes Antonio Carlos Francesconi do Valle |
| author_sort | Priscila Marques de Macedo |
| collection | DOAJ |
| description | <h4>Introduction</h4>In 2020, we reported the first patient with concomitant COVID-19 and paracoccidioidomycosis (PCM). Since then, no other cases have been recorded in the literature. We aim to update information on the occurrence of COVID-19 in patients with PCM followed at a reference center for infectious diseases at Rio de Janeiro, Brazil.<h4>Methods</h4>We reviewed the medical records from patients diagnosed with PCM who presented with clinical symptoms, radiological findings, and/or laboratory diagnosis of COVID-19 at any time during their acute or follow-up care. The clinical profiles of these patients were described.<h4>Results</h4>Between March 2020 and September 2022, we identified six individuals with COVID-19 among the 117 patients with PCM evaluated. The median age was 38 years and the male to female ratio 2:1. Most patients (n = 5) presented for evaluation due to acute PCM. The severity of COVID-19 ranged from mild to severe in acute PCM and only the single patient with chronic PCM died.<h4>Conclusions</h4>There is a range of disease severity in COVID-19 and PCM co-infection and concomitant disease may represent a severe association, especially in the chronic type of the mycosis with pulmonary involvement. As COVID-19 and chronic PCM share similar clinical aspects and PCM is neglected, it is probable that COVID-19 has been hampering simultaneous PCM diagnosis, which can explain the absence of new co-infection reports. With the continued persistence of COVID-19 globally, these findings further suggest that more attention by providers is necessary to identify co-infections with Paracoccidioides. |
| first_indexed | 2024-03-13T09:09:34Z |
| format | Article |
| id | doaj.art-2ae0e4fa1c2247a7ab360840c65e2e98 |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-03-13T09:09:34Z |
| publishDate | 2023-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-2ae0e4fa1c2247a7ab360840c65e2e982023-05-27T05:31:57ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352023-05-01175e001132210.1371/journal.pntd.0011322COVID-19 in patients with paracoccidioidomycosis.Priscila Marques de MacedoLorena Macedo Pestana BenkoEduardo Mastrangelo Marinho FalcãoJoshua D NosanchukRodrigo Almeida-PaesAntonio Carlos Francesconi do Valle<h4>Introduction</h4>In 2020, we reported the first patient with concomitant COVID-19 and paracoccidioidomycosis (PCM). Since then, no other cases have been recorded in the literature. We aim to update information on the occurrence of COVID-19 in patients with PCM followed at a reference center for infectious diseases at Rio de Janeiro, Brazil.<h4>Methods</h4>We reviewed the medical records from patients diagnosed with PCM who presented with clinical symptoms, radiological findings, and/or laboratory diagnosis of COVID-19 at any time during their acute or follow-up care. The clinical profiles of these patients were described.<h4>Results</h4>Between March 2020 and September 2022, we identified six individuals with COVID-19 among the 117 patients with PCM evaluated. The median age was 38 years and the male to female ratio 2:1. Most patients (n = 5) presented for evaluation due to acute PCM. The severity of COVID-19 ranged from mild to severe in acute PCM and only the single patient with chronic PCM died.<h4>Conclusions</h4>There is a range of disease severity in COVID-19 and PCM co-infection and concomitant disease may represent a severe association, especially in the chronic type of the mycosis with pulmonary involvement. As COVID-19 and chronic PCM share similar clinical aspects and PCM is neglected, it is probable that COVID-19 has been hampering simultaneous PCM diagnosis, which can explain the absence of new co-infection reports. With the continued persistence of COVID-19 globally, these findings further suggest that more attention by providers is necessary to identify co-infections with Paracoccidioides.https://doi.org/10.1371/journal.pntd.0011322 |
| spellingShingle | Priscila Marques de Macedo Lorena Macedo Pestana Benko Eduardo Mastrangelo Marinho Falcão Joshua D Nosanchuk Rodrigo Almeida-Paes Antonio Carlos Francesconi do Valle COVID-19 in patients with paracoccidioidomycosis. PLoS Neglected Tropical Diseases |
| title | COVID-19 in patients with paracoccidioidomycosis. |
| title_full | COVID-19 in patients with paracoccidioidomycosis. |
| title_fullStr | COVID-19 in patients with paracoccidioidomycosis. |
| title_full_unstemmed | COVID-19 in patients with paracoccidioidomycosis. |
| title_short | COVID-19 in patients with paracoccidioidomycosis. |
| title_sort | covid 19 in patients with paracoccidioidomycosis |
| url | https://doi.org/10.1371/journal.pntd.0011322 |
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