Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma
Cigarette smoking, exposure to secondhand smoke, and arsenic exposure are well known risk factors for developing urothelial carcinoma (UC). We investigated the combined effects of cigarette smoking, exposure to secondhand smoke, and the presence of urinary total arsenic on the risk of developing UC....
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-09-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664613001794 |
| _version_ | 1818022598900973568 |
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| author | Chia-Chang Wu Mei-Chieh Chen Yung-Kai Huang Chao-Yuan Huang Li-An Lai Chi-Jung Chung Horng-Sheng Shiue Yeong-Shiau Pu Ying-Chin Lin Bor-Cheng Han Yuan-Hung Wang Yu-Mei Hsueh |
| author_facet | Chia-Chang Wu Mei-Chieh Chen Yung-Kai Huang Chao-Yuan Huang Li-An Lai Chi-Jung Chung Horng-Sheng Shiue Yeong-Shiau Pu Ying-Chin Lin Bor-Cheng Han Yuan-Hung Wang Yu-Mei Hsueh |
| author_sort | Chia-Chang Wu |
| collection | DOAJ |
| description | Cigarette smoking, exposure to secondhand smoke, and arsenic exposure are well known risk factors for developing urothelial carcinoma (UC). We investigated the combined effects of cigarette smoking, exposure to secondhand smoke, and the presence of urinary total arsenic on the risk of developing UC.
Methods: We conducted a hospital-based, case–control study involving 261 UC patients and 672 cancer-free control individuals between September 2002 and May 2009.
Results: Individuals who had smoked <100 cigarettes in their lifetime (never smokers) and had a high urinary total arsenic level (≥15.40 μg/g creatinine), and those who had smoked >100 cigarettes in their lifetime (ever smokers) and had a high urinary total arsenic level, had increased risks of developing UC (3.20-fold and 6.45-fold greater), respectively, compared to individuals who were never smokers and had a low urinary total arsenic level. Individuals who had high urinary total arsenic levels and had been exposed to secondhand smoke, and individuals with high urinary arsenic levels who had not been exposed to secondhand smoke, had increased chances (2.71-fold and 5.00-fold greater, respectively) of developing UC, compared to individuals who were not exposed to secondhand smoke and had low urinary total arsenic levels. Ever smokers who had been exposed to secondhand smoke and had a high urinary total arsenic level had the greatest increased risk for developing UC (10.82-fold greater).
Conclusion: Individuals in a Taiwanese population who smoked cigarettes, were exposed to secondhand smoke, and a high urinary total arsenic level, had a significant risk for developing UC. |
| first_indexed | 2024-12-10T03:30:59Z |
| format | Article |
| id | doaj.art-2ae0e5d35b324773922e6e1f2deb8c80 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-10T03:30:59Z |
| publishDate | 2013-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-2ae0e5d35b324773922e6e1f2deb8c802022-12-22T02:03:48ZengElsevierJournal of the Formosan Medical Association0929-66462013-09-01112955456010.1016/j.jfma.2013.05.012Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinomaChia-Chang Wu0Mei-Chieh Chen1Yung-Kai Huang2Chao-Yuan Huang3Li-An Lai4Chi-Jung Chung5Horng-Sheng Shiue6Yeong-Shiau Pu7Ying-Chin Lin8Bor-Cheng Han9Yuan-Hung Wang10Yu-Mei Hsueh11School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, TaiwanDepartment of Microbiology and Immunology, College of Medicine, Taipei Medical University, Taipei, TaiwanSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Urology, National Taiwan University Hospital, College of Medicine National Taiwan University, Taipei, TaiwanSchool of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, TaiwanDepartment of Health Risk Management, College of Public Health, China Medical University and Hospital, Taichung, TaiwanDepartment of Chinese Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Urology, National Taiwan University Hospital, College of Medicine National Taiwan University, Taipei, TaiwanDepartment of Family Medicine, Shung Ho Hospital, Taipei Medical University, Taipei, TaiwanSchool of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, TaiwanDepartment of Urology, Taipei Medical University–Shuang Ho Hospital, Taipei, TaiwanDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanCigarette smoking, exposure to secondhand smoke, and arsenic exposure are well known risk factors for developing urothelial carcinoma (UC). We investigated the combined effects of cigarette smoking, exposure to secondhand smoke, and the presence of urinary total arsenic on the risk of developing UC. Methods: We conducted a hospital-based, case–control study involving 261 UC patients and 672 cancer-free control individuals between September 2002 and May 2009. Results: Individuals who had smoked <100 cigarettes in their lifetime (never smokers) and had a high urinary total arsenic level (≥15.40 μg/g creatinine), and those who had smoked >100 cigarettes in their lifetime (ever smokers) and had a high urinary total arsenic level, had increased risks of developing UC (3.20-fold and 6.45-fold greater), respectively, compared to individuals who were never smokers and had a low urinary total arsenic level. Individuals who had high urinary total arsenic levels and had been exposed to secondhand smoke, and individuals with high urinary arsenic levels who had not been exposed to secondhand smoke, had increased chances (2.71-fold and 5.00-fold greater, respectively) of developing UC, compared to individuals who were not exposed to secondhand smoke and had low urinary total arsenic levels. Ever smokers who had been exposed to secondhand smoke and had a high urinary total arsenic level had the greatest increased risk for developing UC (10.82-fold greater). Conclusion: Individuals in a Taiwanese population who smoked cigarettes, were exposed to secondhand smoke, and a high urinary total arsenic level, had a significant risk for developing UC.http://www.sciencedirect.com/science/article/pii/S0929664613001794arsenic methylation capacitycigarette smokingenvironmental tobacco smokeurothelial carcinoma |
| spellingShingle | Chia-Chang Wu Mei-Chieh Chen Yung-Kai Huang Chao-Yuan Huang Li-An Lai Chi-Jung Chung Horng-Sheng Shiue Yeong-Shiau Pu Ying-Chin Lin Bor-Cheng Han Yuan-Hung Wang Yu-Mei Hsueh Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma Journal of the Formosan Medical Association arsenic methylation capacity cigarette smoking environmental tobacco smoke urothelial carcinoma |
| title | Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma |
| title_full | Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma |
| title_fullStr | Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma |
| title_full_unstemmed | Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma |
| title_short | Environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma |
| title_sort | environmental tobacco smoke and arsenic methylation capacity are associated with urothelial carcinoma |
| topic | arsenic methylation capacity cigarette smoking environmental tobacco smoke urothelial carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S0929664613001794 |
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