Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence
Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in older women result in higher rates of miscarriage with aneuploidy. Age-related decline in fertility is strongly attributed to ovarian aging, diminished ovarian reserves, and decreased developmental competence of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00811/full |
| _version_ | 1818174196906196992 |
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| author | Hiroyuki Sasaki Toshio Hamatani Shintaro Kamijo Maki Iwai Masato Kobanawa Seiji Ogawa Kenji Miyado Mamoru Tanaka |
| author_facet | Hiroyuki Sasaki Toshio Hamatani Shintaro Kamijo Maki Iwai Masato Kobanawa Seiji Ogawa Kenji Miyado Mamoru Tanaka |
| author_sort | Hiroyuki Sasaki |
| collection | DOAJ |
| description | Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in older women result in higher rates of miscarriage with aneuploidy. Age-related decline in fertility is strongly attributed to ovarian aging, diminished ovarian reserves, and decreased developmental competence of oocytes. In this review, we discuss the underlying mechanisms of age-related decline in oocyte quality, focusing on oxidative stress (OS) in oocytes. The primary cause is the accumulation of spontaneous damage to the mitochondria arising from increased reactive oxygen species (ROS) in oocytes, generated by the mitochondria themselves during daily biological metabolism. Mitochondrial dysfunction reduces ATP synthesis and influences the meiotic spindle assembly responsible for chromosomal segregation. Moreover, reproductively aged oocytes produce a decline in the fidelity of the protective mechanisms against ROS, namely the ROS-scavenging metabolism, repair of ROS-damaged DNA, and the proteasome and autophagy system for ROS-damaged proteins. Accordingly, increased ROS and increased vulnerability of oocytes to ROS lead to spindle instability, chromosomal abnormalities, telomere shortening, and reduced developmental competence of aged oocytes. |
| first_indexed | 2024-12-11T19:40:34Z |
| format | Article |
| id | doaj.art-2ae151d5dc3346f297776c085bcfe753 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T19:40:34Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2ae151d5dc3346f297776c085bcfe7532022-12-22T00:53:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-11-011010.3389/fendo.2019.00811478890Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental CompetenceHiroyuki Sasaki0Toshio Hamatani1Shintaro Kamijo2Maki Iwai3Masato Kobanawa4Seiji Ogawa5Kenji Miyado6Mamoru Tanaka7Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, JapanNational Center for Child Health and Development (NCCHD), Tokyo, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, JapanReproductive capacity in women starts to decline beyond their mid-30s and pregnancies in older women result in higher rates of miscarriage with aneuploidy. Age-related decline in fertility is strongly attributed to ovarian aging, diminished ovarian reserves, and decreased developmental competence of oocytes. In this review, we discuss the underlying mechanisms of age-related decline in oocyte quality, focusing on oxidative stress (OS) in oocytes. The primary cause is the accumulation of spontaneous damage to the mitochondria arising from increased reactive oxygen species (ROS) in oocytes, generated by the mitochondria themselves during daily biological metabolism. Mitochondrial dysfunction reduces ATP synthesis and influences the meiotic spindle assembly responsible for chromosomal segregation. Moreover, reproductively aged oocytes produce a decline in the fidelity of the protective mechanisms against ROS, namely the ROS-scavenging metabolism, repair of ROS-damaged DNA, and the proteasome and autophagy system for ROS-damaged proteins. Accordingly, increased ROS and increased vulnerability of oocytes to ROS lead to spindle instability, chromosomal abnormalities, telomere shortening, and reduced developmental competence of aged oocytes.https://www.frontiersin.org/article/10.3389/fendo.2019.00811/fulloxidative streemitochondrial dysfunctionantioxidantsoocyte agingER stress |
| spellingShingle | Hiroyuki Sasaki Toshio Hamatani Shintaro Kamijo Maki Iwai Masato Kobanawa Seiji Ogawa Kenji Miyado Mamoru Tanaka Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence Frontiers in Endocrinology oxidative stree mitochondrial dysfunction antioxidants oocyte aging ER stress |
| title | Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence |
| title_full | Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence |
| title_fullStr | Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence |
| title_full_unstemmed | Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence |
| title_short | Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence |
| title_sort | impact of oxidative stress on age associated decline in oocyte developmental competence |
| topic | oxidative stree mitochondrial dysfunction antioxidants oocyte aging ER stress |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00811/full |
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