Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila
Abstract Most real-world behaviors – such as odor-guided locomotion - are performed with incomplete information. Activity in olfactory receptor neuron (ORN) classes provides information about odor identity but not the location of its source. In this study, we investigate the sensorimotor transformat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-42613-8 |
| _version_ | 1797647243954618368 |
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| author | Liangyu Tao Samuel P. Wechsler Vikas Bhandawat |
| author_facet | Liangyu Tao Samuel P. Wechsler Vikas Bhandawat |
| author_sort | Liangyu Tao |
| collection | DOAJ |
| description | Abstract Most real-world behaviors – such as odor-guided locomotion - are performed with incomplete information. Activity in olfactory receptor neuron (ORN) classes provides information about odor identity but not the location of its source. In this study, we investigate the sensorimotor transformation that relates ORN activation to locomotion changes in Drosophila by optogenetically activating different combinations of ORN classes and measuring the resulting changes in locomotion. Three features describe this sensorimotor transformation: First, locomotion depends on both the instantaneous firing frequency (f) and its change (df); the two together serve as a short-term memory that allows the fly to adapt its motor program to sensory context automatically. Second, the mapping between (f, df) and locomotor parameters such as speed or curvature is distinct for each pattern of activated ORNs. Finally, the sensorimotor mapping changes with time after odor exposure, allowing information integration over a longer timescale. |
| first_indexed | 2024-03-11T15:13:26Z |
| format | Article |
| id | doaj.art-2ae1cf12fc1749208011016a95bfc69e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-11T15:13:26Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2ae1cf12fc1749208011016a95bfc69e2023-10-29T12:30:11ZengNature PortfolioNature Communications2041-17232023-10-0114112210.1038/s41467-023-42613-8Sensorimotor transformation underlying odor-modulated locomotion in walking DrosophilaLiangyu Tao0Samuel P. Wechsler1Vikas Bhandawat2School of Biomedical Engineering and Health Sciences, Drexel UniversitySchool of Biomedical Engineering and Health Sciences, Drexel UniversitySchool of Biomedical Engineering and Health Sciences, Drexel UniversityAbstract Most real-world behaviors – such as odor-guided locomotion - are performed with incomplete information. Activity in olfactory receptor neuron (ORN) classes provides information about odor identity but not the location of its source. In this study, we investigate the sensorimotor transformation that relates ORN activation to locomotion changes in Drosophila by optogenetically activating different combinations of ORN classes and measuring the resulting changes in locomotion. Three features describe this sensorimotor transformation: First, locomotion depends on both the instantaneous firing frequency (f) and its change (df); the two together serve as a short-term memory that allows the fly to adapt its motor program to sensory context automatically. Second, the mapping between (f, df) and locomotor parameters such as speed or curvature is distinct for each pattern of activated ORNs. Finally, the sensorimotor mapping changes with time after odor exposure, allowing information integration over a longer timescale.https://doi.org/10.1038/s41467-023-42613-8 |
| spellingShingle | Liangyu Tao Samuel P. Wechsler Vikas Bhandawat Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila Nature Communications |
| title | Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila |
| title_full | Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila |
| title_fullStr | Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila |
| title_full_unstemmed | Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila |
| title_short | Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila |
| title_sort | sensorimotor transformation underlying odor modulated locomotion in walking drosophila |
| url | https://doi.org/10.1038/s41467-023-42613-8 |
| work_keys_str_mv | AT liangyutao sensorimotortransformationunderlyingodormodulatedlocomotioninwalkingdrosophila AT samuelpwechsler sensorimotortransformationunderlyingodormodulatedlocomotioninwalkingdrosophila AT vikasbhandawat sensorimotortransformationunderlyingodormodulatedlocomotioninwalkingdrosophila |