Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.

Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.

Misfolding- and aggregation-prone proteins underlying Parkinson's, Huntington's and Machado-Joseph diseases, namely alpha-synuclein, huntingtin, and ataxin-3 respectively, adopt numerous intracellular conformations during pathogenesis, including globular intermediates and insoluble amyloid...

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Bibliographic Details
Main Authors: Erik Kvam, Brent L Nannenga, Min S Wang, Zongjian Jia, Michael R Sierks, Anne Messer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2683928?pdf=render

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http://europepmc.org/articles/PMC2683928?pdf=render

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