BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report
We report the case of a 32-year-old man with a caecal adenocarcinoma with major lymph node extension and peritoneal carcinomatosis, presenting a BRAF-K601E mutation. A triplet (5FU plus oxaliplatin plus irinotecan) combination with bevacizumab achieved tumor control but the disease progressed immedi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2019-06-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/500857 |
| _version_ | 1811193280497451008 |
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| author | Laure Moisset Judith Raimbourg Sandrine Hiret Jonathan Dauve Michèle Boisdron-Celle Hélène Senellart Jean-Luc Raoul |
| author_facet | Laure Moisset Judith Raimbourg Sandrine Hiret Jonathan Dauve Michèle Boisdron-Celle Hélène Senellart Jean-Luc Raoul |
| author_sort | Laure Moisset |
| collection | DOAJ |
| description | We report the case of a 32-year-old man with a caecal adenocarcinoma with major lymph node extension and peritoneal carcinomatosis, presenting a BRAF-K601E mutation. A triplet (5FU plus oxaliplatin plus irinotecan) combination with bevacizumab achieved tumor control but the disease progressed immediately after cessation and the patient died 8 months after the diagnosis. A short review of BRAF non-V600E mutations shows that outcome and clinical features depend on the mutation. |
| first_indexed | 2024-04-12T00:05:45Z |
| format | Article |
| id | doaj.art-2ae4bd1e174f474ca23c19624c2e531c |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T00:05:45Z |
| publishDate | 2019-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-2ae4bd1e174f474ca23c19624c2e531c2022-12-22T03:56:06ZengKarger PublishersCase Reports in Oncology1662-65752019-06-0112242642910.1159/000500857500857BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case ReportLaure MoissetJudith RaimbourgSandrine HiretJonathan DauveMichèle Boisdron-CelleHélène SenellartJean-Luc RaoulWe report the case of a 32-year-old man with a caecal adenocarcinoma with major lymph node extension and peritoneal carcinomatosis, presenting a BRAF-K601E mutation. A triplet (5FU plus oxaliplatin plus irinotecan) combination with bevacizumab achieved tumor control but the disease progressed immediately after cessation and the patient died 8 months after the diagnosis. A short review of BRAF non-V600E mutations shows that outcome and clinical features depend on the mutation.https://www.karger.com/Article/FullText/500857Metastatic colorectal cancerPrognosisMolecular characterizationBRAF mutation |
| spellingShingle | Laure Moisset Judith Raimbourg Sandrine Hiret Jonathan Dauve Michèle Boisdron-Celle Hélène Senellart Jean-Luc Raoul BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report Case Reports in Oncology Metastatic colorectal cancer Prognosis Molecular characterization BRAF mutation |
| title | BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report |
| title_full | BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report |
| title_fullStr | BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report |
| title_full_unstemmed | BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report |
| title_short | BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report |
| title_sort | braf non v600e mutated metastatic colorectal cancer in a young patient discussion from a case report |
| topic | Metastatic colorectal cancer Prognosis Molecular characterization BRAF mutation |
| url | https://www.karger.com/Article/FullText/500857 |
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